Results 211 to 220 of about 4,022,212 (305)

Weight gain and brain development in the ABCD study cohort: A decade of insight and the road ahead. [PDF]

Dev Cogn Neurosci
Adise S, Buchbinder N, Huber RS, Kiss O, Ma J, Makowski C, Leblanc KH, Akande O, Lehrmann C, Yurgelun-Todd D, Rhee KE.   +10 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Metformin in the management of antipsychotic-induced weight gain – why the ‘weight’?

Frontiers in Psychiatry
Ita Fitzgerald, Ita Fitzgerald, Laura J. Sahm, Laura J. Sahm, Laura J. Sahm, Ciara Ní Dhubhlaing, Ciara Ní Dhubhlaing, Sarah O’Dwyer, Jean O’Connell, Jean O’Connell, Jennifer Torrens, Erin K. Crowley   +11 more
doaj   +1 more source

Infections in Infancy and Association with Long-Term Weight Gain and Obesity in Children, Southern California, USA. [PDF]

Emerg Infect Dis
Taylor ZW, Lin JC.
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Magnitude and determinants of gestational weight gain in Ethiopia: a systematic review and meta-analysis. [PDF]

Matern Health Neonatol Perinatol
Mihiret GT, Melesse YD, Mulueh AA, Abneh AA, Ewunetie AA, Amha H, Lamesgen A, Gedif G, Getnet A, Alamneh AA, Kassie TD, Siferih M, Gete M.   +12 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Effects of different types of physical exercises on gestational weight gain: a systematic review and network meta-analysis. [PDF]

Front Nutr
Liu C, Hu S, Shao X, Lin Z, Li M, Qian S, Huang X.   +6 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source