Results 51 to 60 of about 6,306 (242)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Pemanfaatan Metode Weighted Aggregated Sum Product Assesment Dalam Keputusan Pemilihan Personal Computer Untuk Kebutuhan Industri Game Developer

, 2023
With the advance of current technology, humanity is at ease to get their task done. Take example of a entertainment industry, the use of a computer is a vital point at developing a game.
Sulistyawan, Perdana Eka Putra, Wibisono, Setyawan   +1 more
core  

Modification of Weighted Aggregated Sum Product Assessment Method to Improve Objective Weighting Accuracy in Multi-Criteria Decision Making

Modification of Weighted Aggregated Sum Product Assessment Method to Improve Objective Weighting Accuracy in Multi-Criteria Decision Making
Multi-criteria decision-making methods (MCDM) have an important role in various fields because they allow decision-makers to consider different aspects or criteria simultaneously. Weighted aggregate quantity product assessment (WASPAS) is a MCDM that combines the advantages of the weighted quantity model (WSM) and weighted product model (WPM ...
Mesran, Mesran, Rohayani, Hetty, Borman, Rohmat Indra, Setiawansyah, Setiawansyah, Suryono, Ryan Randy, Rakhmatdedig, Rakhmat Dedi Gunawan, Aryanti, Riska   +6 more
openaire   +3 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Subject Selection Decision Support System Using the Weighted Aggregated Sum Product Assessment Method

INOVTEK Polbeng - Seri Informatika
High school subject selection is crucial for aligning with students' interests and goals, but manual processes are often time-consuming and prone to errors. This study developed a decision support system using the WASPAS method, which combines WSM and WPM to produce a more stable and consistent evaluation of alternatives.
Mhd. Liandra Setiawan, null Sriani
openaire   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Sistem Pendukung Keputusan Penerima Beasiswa Bidikmisi Universitas Muhammadiyah Gresik Dengan Metode WASPAS (Weighted Aggregated Sum Product Assessment) (“Studi Kasus Biro P2MB & Humas Universitas Muhammadiyah Gresik”) [PDF]

, 2021
Beasiswa bidikmisi UMG merupakan salah satu program bantuan biaya Pendidikan yang diberikanoleh instansi pendidikan Universitas Muhammadiyah Gresik. Penyeleksian calon penerima beasiswa bidikmisi UMG yang dilakukan oleh Biro Pemasaran dan Penerimaan ...
Syifa', Amin
core  

Interval-valued fermatean fuzzy sets with multi-criteria weighted aggregated sum product assessment-based decision analysis framework. [PDF]

Neural Comput Appl, 2022
Rani P, Mishra AR.
europepmc   +1 more source

Selection of Head of Study Program using Weighted Aggregated Sum Product Assessment (WASPAS) method

Internet of Things and Artificial Intelligence Journal
Selecting a Head of Study Program is a crucial strategic decision in education, particularly in Vocational High Schools. At the Software Engineering Study Program Vocational School Sitibanun Sigambal, Labuhanbatu, Rantau Prapat, this process becomes highly complex due to the involvement of various criteria, such as Psychotest Scores, IQ Tests ...
Ramadani Ramadani, Riszki Fadillah, Intan Nur Fitriyani   +2 more
openaire   +1 more source