Results 81 to 90 of about 92,089 (307)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Quality Measures of Parameter Tuning for Aggregated Multi-Objective Temporal Planning [PDF]

, 2013
Parameter tuning is recognized today as a crucial ingredient when tackling an optimization problem. Several meta-optimization methods have been proposed to find the best parameter set for a given optimization algorithm and (set of) problem instances ...
Dréo, Johann, Khouadjia, Mostepha Redouane, Savéant, Pierre, Schoenauer, Marc, Vidal, Vincent   +4 more
core   +3 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Compensation and Weights for Trade-offs in Engineering Design: Beyond the Weighted Sum [PDF]

, 2005
Multicriteria decision support methods are common in engineering design. These methods typically rely on a summation of weighted attributes to accomplish trade-offs among competing objectives.
Antonsson, Erik K., Scott, Michael J.
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

A Novel Intuitionistic Fuzzy Decision Support System Based on Extended WASPAS Method: A Case Study for the Selection of Basketball Players and Basketball Fields for Maximum Performance

IEEE Access
The choice of basketball players and their playing field selection represents a vital decision-making (DM) process that determines team success and game results.
Chenhan Xu, Xiaotong Yuan
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Assessment of Hand Hygienic Materials for Nursing Staff at Hospitals With WASPAS Technique and Picture Fuzzy Information

IEEE Access
Hand hygiene products are essential for infection prevention and control (IPC) measures in healthcare organizations, contributing to society. Lack of hygiene practices may expose pathogenic agents that cause the spread of epidemics and increase people ...
Liu Tengfei, Wang Jing, Xiao Yuan, Gao Jing, Wang Teng, Lan Tian, Yuan Meijin, Li Baoliang   +7 more
doaj   +1 more source

Global impacts of energy demand on the freshwater resources of nations [PDF]

, 2015
The growing geographic disconnect between consumption of goods, the extraction and processing of resources, and the environmental impacts associated with production activities makes it crucial to factor global trade into sustainability assessments. Using
Ann Muggeridge, Cullis, Döll, Elizabeth Farmer, Felix Eigenbrod, Gail Taylor, Gareth Brown, Hussey, John Barrett, Jörn P. W. Scharlemann, Kate A. Scott, Kounina, Luck, Martina Flörke, McDougall, Pittock, Robert Alan Holland, Robert M. Ewers, Valerie Kapos, Vassolo, Wiedmann, Wu   +21 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source