Results 101 to 110 of about 1,126,452 (304)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

New Numerical Software for Model and Controller Reduction [PDF]

, 2002
In this report we describe the recently developed model and controller reduction software for SLICOT within Task II.B of the NICONET Project. A powerful collection of user callable Fortran 77 routines has been implemented based on the latest algorithmic ...
Varga, Andras
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Structured low-rank approximation with missing data

The approach of SIAM J. Matrix Anal. Appl., 26(4):1083--1099 for solving structured total least squares problems is generalized to weighted structured low-rank approximation with missing data. The method proposed is based on elimination of the correction
Markovsky, Ivan, Usevich, Konstantin
core   +1 more source

On the Approximation Process of Shifted-Knots Bivariate Stancu-Type Kantorovich Operators

Journal of Mathematics
This paper focuses on defining bivariate Stancu-type Kantorovich operators with the technique associated with the idea of shifted knots. The degree of approximation and weighted approximation of these bivariate operators are estimated, respectively, by ...
Abdullah Alotaibi
doaj   +1 more source

Approximation on the sphere by weighted Fourier expansions

Journal of Applied Mathematics, 2005
The main theme of this paper is the approximation on the sphere by weighted sums of spherical harmonics. We give necessary and sufficient conditions on the weights for convergence in both the continuous and the LP cases.
V. A. Menegatto, A. C. Piantella
doaj   +1 more source

Coprime Factor Reduction of H-infinity Controllers [PDF]

, 2003
We consider the efficient solution of the coprime factorization based H infinity controller approximation problems by using frequency-weighted balancing related model reduction approaches.
Varga, Andras
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Smooth approximation in weighted Sobolev spaces [PDF]

, 1997
summary:We give necessary and sufficient conditions for the equality $H=W$ in weighted Sobolev spaces. We also establish a Rellich-Kondrachov compactness theorem as well as a Lusin type approximation by Lipschitz functions in weighted Sobolev ...
Kilpeläinen, T.
core   +1 more source