Results 81 to 90 of about 631,044 (314)

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

On the approximation of Kantorovich-type Szàsz-Charlier operators

Demonstratio Mathematica
In this study, we introduce the Kantorovich-type modified Szàsz-Charlier operators and examine their approximation properties within the framework of fractional modeling and control theory. These operators are defined using the Korovkin-type theorem, and
Karabıyık Ümit, Ayık Adem
doaj   +1 more source

Certain approximation properties of Brenke polynomials using Jakimovski–Leviatan operators

Journal of Inequalities and Applications, 2021
In this article, we establish the approximation by Durrmeyer type Jakimovski–Leviatan operators involving the Brenke type polynomials. The positive linear operators are constructed for the Brenke polynomials, and thus approximation properties for these ...
Shahid Ahmad Wani, M. Mursaleen, Kottakkaran Sooppy Nisar   +2 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Quantitative-Voronovskaya and Grüss-Voronovskaya type theorems for Szász-Durrmeyer type operators blended with multiple Appell polynomials

Journal of Inequalities and Applications, 2017
In this paper, we establish a link between the Szász-Durrmeyer type operators and multiple Appell polynomials. We study a quantitative-Voronovskaya type theorem in terms of weighted modulus of smoothness using sixth order central moment and Grüss ...
Trapti Neer, Purshottam Narain Agrawal
doaj   +1 more source

Generalized Weighted Statistical Convergence for Double Sequences of Fuzzy Numbers and Associated Korovkin-Type Approximation Theorem

Journal of Function Spaces, 2020
We define the notions of weighted λ,μ-statistical convergence of order γ1,γ2 and strongly weighted λ,μ-summability of γ1,γ2 for fuzzy double sequences, where ...
Abdullah Alotaibi
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

New Characterization for Nonlinear Weighted Best Simultaneous Approximation

International Journal of Mathematics and Mathematical Sciences, 2009
This paper is concerned with the problem of a wide class of weighted best simultaneous approximation in normed linear spaces, and it establishes a new characterization result for the class of approximation by virtue of the notion of simultaneous regular ...
Xianfa Luo, Delin Wu, Jinsu He
doaj   +1 more source

Approximation Schemes for Maximum Weight Independent Set of Rectangles

, 2013
In the Maximum Weight Independent Set of Rectangles (MWISR) problem we are given a set of n axis-parallel rectangles in the 2D-plane, and the goal is to select a maximum weight subset of pairwise non-overlapping rectangles. Due to many applications, e.g.
Adamaszek, Anna, Wiese, Andreas
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source