Results 191 to 200 of about 4,397 (258)

Building trust in the integration of artificial intelligence into chemical risk assessment: findings from the 2024 ECETOC workshop. [PDF]

Arch Toxicol
Gant TW, Boxall A, Burgwinkel D, Zare Jeddi M, Djidrovski I, Friedrichs S, Hardy B, Hartung T, Holland D, Karwath A, Kienhuis A, Kleinstreuer N, Lin Z, Marczylo EL, Marvuglia A, Qian H, van Ravenzwaay B, Rees P, Sarimveis H, Tralau T, Wilmot L, Zalewski A, Rouquié D.   +22 more
europepmc   +1 more source

Design, Synthesis, and Biological Evaluation of Chiral Urea and Thiourea Derivatives as Multitarget‐Directed Anti‐Alzheimer Agents

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT A series of novel chiral urea and thiourea compounds were designed as multitarget‐directed ligands for Alzheimer's disease and evaluated against hAChE, hBChE, and hMAO‐B, with exploratory assessment of HSD10. These chiral compounds were synthesized and fully characterized, and their enantiopurity was confirmed via HPLC.
Sule Erol Gunal, Senel Teke Tuncel, İlke Demir, İpek Baysal, Gökçen Telli, Safiye Sag Erdem, Gulberk Ucar, Michaela Hanzlova, Kamil Musilek, İlknur Dogan, Nesrin Gokhan Kelekci   +10 more
wiley   +1 more source

Personalized polygenic profiling based on the genetic architecture of lipid metabolism in the Russian population. [PDF]

Front Cardiovasc Med
Mamchur A, Bruttan M, Daniel V, Kashtanova D, Zelenova E, Dzhumaniiazova I, Ivanov M, Matkava L, Blinova O, Mitrofanov S, Golubnikova L, Kumar N, Maralova E, Shingaliev A, Ezhov M, Meshkov A, Chubykina U, Pogorelova O, Tripoten M, Balahonova T, Viskova A, Komarova M, Gurtsiev T, Gomyranova N, Vorobeva Y, Hotuleva A, Kolyaskina M, Yudin V, Makarov V, Keskinov A, Kuzmina L, Boytsov S, Yudin S, Skvortsova V.   +33 more
europepmc   +1 more source

Is Blood Thicker Than Water? The Influence of Kin Within a Bull Shark Social Network

Ecology and Evolution, Volume 16, Issue 8, August 2026.
This study investigates how kinship (“kinfluence”) shapes social structure in an aggregation of adult bull sharks in Fiji by integrating genomic relatedness, pedigree reconstruction, and detailed behavioral data. It reveals that while genetic relatedness has a small but significant influence on social behavior, especially among males, kin‐category ...
Natasha D. Marosi, Darren P. Croft, David M. P. Jacoby, Samuel Ellis, Andrew M. Griffiths   +4 more
wiley   +1 more source

A Law of Large Numbers for Local Patterns in Schur Measures and a Schur Process. [PDF]

J Theor Probab
Lazag P.
europepmc   +1 more source

Unique Population or Unique Species? Genetic Insights Into the Pygmy Freshwater Crocodiles of Northern Australia

Ecology and Evolution, Volume 16, Issue 8, August 2026.
There is debate over whether isolated populations of “pygmy” Australian freshwater crocodiles are a unique species. This is a conservation concern as these populations face unique challenges. We found some population differences which support these populations as being ecologically unique and valuable for targeted conservation.
Katherine Brittain, Torre Muhlbach, Rui Cao, Jose Luis Mijangos, Dean Yibarbuk, Erin O'Brien, Ruchira Somaweera, Nancy N. FitzSimmons, Jaime Gongora   +8 more
wiley   +1 more source

A progeria syndrome links DNA hypermethylation to age-related pathology. [PDF]

Nat Genet
Sarni D, Neary G, Carroll PL, Vink CS, Billard CV, Isobe T, Weng X, Portman JR, McCartney DL, Heyn P, van 't Hof RJ, Morrison LR, Martin CA, Stok C, Harley ME, Leitch A, van den Ancker M, Robertson N, Kitto L, Clark R, Rennie M, Popravko A, McClure JJ, Parry DA, Camiolo G, Leah T, Jakobczyk H, Megaw R, McKie L, Marshall GF, Balkic N, Amiel J, Barragán Arévalo T, Bronken McCarthy G, Buchanan CA, Buffet A, Cascón A, Cogne B, Conrad S, Cueto-González AM, Currás-Freixes M, Houge GD, Fong CT, George-Abraham JK, Gibson K, Ibáñez L, Longo N, Lussey-Lepoutre C, Miller BS, Moles-Fernandez A, Pillai NR, Tvrdik T, Vincent M, Yokoyama E, Abbott CM, Sanchez-Luque FJ, Ottersbach K, De Bari C, Roelofs AJ, Tillotson R, Kranc KR, Brown SJ, Marioni RE, Crisan M, Göttgens B, Henderson NC, Semple RK, Myant KB, Dzierzak E, Reijns MAM, Sproul D, Jackson AP.   +71 more
europepmc   +1 more source

Food Availability Cannot Explain Dispersal and Settlement Decisions of a Grassland Bird

Ecology and Evolution, Volume 16, Issue 8, August 2026.
We test a commonly assumed explanation for animal movements—namely that food availability shapes where animals disperse to. Based on the results of four strong predictions, 3 years of data, and hundreds of individual birds, we show that food cannot explain breeding dispersal in this system, and we propose alternative explanations consistent with our ...
Emily J. Williams, Theo K. Michaels, W. Alice Boyle   +2 more
wiley   +1 more source

GABRB3 Gene Polymorphisms Influences the Analgesic Response to Acupuncture Treatment in Patients With Chronic Knee Pain: A Randomized Controlled Neuroimaging Transcriptomics Study. [PDF]

FASEB J
Wu S, Wu W, Zhou J, Cheng S, Dong X, Chen Y, Tang C, He W, Zeng F, Liang F, Li Z.   +10 more
europepmc   +1 more source

De‐Carbonizing the Transport Sector on the University Campus: A Techno‐Economic‐Environment Assessment and Optimization of PV Fed Electric Bicycles Amid Global Fuel Crisis

Energy Science &Engineering, Volume 14, Issue 8, Page 3788-3810, August 2026.
This study develops and evaluates a solar PV‐fed electric bicycle system optimized for university campuses in Pakistan. The techno‐economic analysis demonstrates significant fuel savings, emission reductions, and sustainability benefits, promoting a cost‐effective, eco‐friendly, and renewable transportation alternative amid rising global fuel and ...
Muhammad Abdullah Khan, Syed Ali Abbas Kazmi, Qamar uddin, Muhammad Umair Iftikhar, Muhammad Waseem   +4 more
wiley   +1 more source