Results 121 to 130 of about 1,675,186 (285)

MULTIPLE CRITERA METHODS WITH FOCUS ON ANALYTIC HIERARCHY PROCESS AND GROUP DECISION MAKING

open access: yesCroatian Operational Research Review, 2010
Managing natural resources is a group multiple criteria decision making problem. In this paper the analytic hierarchy process is the chosen method for handling the natural resource problems. The one decision maker problem is discussed and, three methods:
Lidija Zadnik-Stirn, Petra Grošelj
doaj  

GrAviPaSt’s Lens to the Past: Unveiling the Evolution of Filamentary Structures

open access: yesThe Astrophysical Journal
This paper examines the evolution of cosmic filaments across redshifts 1, 0.5, and 0 using the IllustrisTNG100-1 magnetohydrodynamical simulation. To achieve this, we introduce GrAviPaSt, a simple, efficient, and parameter-free filament identification ...
Parsa Ghafour, Saeed Tavasoli
doaj   +1 more source

The Weighting Process in the SHIW [PDF]

open access: yes
The design of a probability sample jointly determines the method used to select sampling units from the population and the estimator of the population parameter.
Ivan Faiella, Romina Gambacorta
core  

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

open access: yesFEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu   +5 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

open access: yesFEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Efficacy and safety of vertebroplasty versus posterior pedicle screw in treating stage III Kummell’s disease without neurological deficits: A systematic review and meta-analysis

open access: yesJournal of International Medical Research
Objective This study aimed to evaluate the efficacy and safety of vertebroplasty versus posterior pedicle screw fixation combined with vertebroplasty in treating stage III Kummell’s disease without neurological deficits.
Binbin Tang   +4 more
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

open access: yesFEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng   +2 more
wiley   +1 more source

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