Results 51 to 60 of about 503,198 (296)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

On a Tauberian theorem for the weighted mean method of summability

open access: yesKuwait Journal of Science, 2015
We investigate conditions needed for a weighted mean summable series to beconvergent by using Kloosterman’s method. The results of this paper generalize thewell known results of Landau and Hardy.
SEFA ANIL SEZER, İBRAHİM ÇANAK
doaj  

Tradeoff between compression ratio and decoding delay of distributed source coding for uplink transmissions in machine-type communication

open access: yesInternational Journal of Distributed Sensor Networks, 2018
Rapid growth of machine-type communications devices challenges the future network with a significant aggregated data traffic. Distributed source coding is a promising technique that compresses data sources and decreases required aggregated data ...
Wen Wang   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

New q-Rung Orthopair Fuzzy Bonferroni Mean Dombi Operators and Their Application in Multiple Attribute Decision Making

open access: yesIEEE Access, 2020
Some q-rung orthopair fuzzy Bonferroni mean Dombi aggregation operators have been developed based on the Bonferroni mean, Dombi T-norm and T-conorm in q-rung orthopair fuzzy environment.
Wei Yang, Yongfeng Pang
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

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