Results 211 to 220 of about 570,334 (284)

Deep learning for fluorescence confocal microscopy image interpretation in radical prostatectomy. [PDF]

BJU Int
Fang L, Mayor N, Light A, Silvanto A, Haider A, Ng C, Gopalakrishnan A, Boaz RJ, Tanaka MB, Khoubehi B, Hellawell G, Almeida-Magana R, Mendes L, Dinneen E, Shaw G, Challacombe B, Cathcart P, Connor MJ, Shah TT, Ahmed HU, Fiorentino F, Giannarou S, Winkler M.   +22 more
europepmc   +1 more source

Integration of Reconfigurable p‐Bit and 1R Crossbar Array for Memristive Probabilistic Computing

Advanced Science, EarlyView.
A memristive probabilistic computing system is demonstrated by integrating stochastic p‐bits based on volatile memristors with a 1R crossbar array encoding interaction weights. The system performs weighted‐sum operations across the array and updates p‐bits iteratively.
Keunho Soh, Ji Eun Kim, Suk Yeop Chun, Su In Hwang, Byung Seok Kim, Young Jae Lee, Ho Won Jang, Jung Ho Yoon   +7 more
wiley   +1 more source

Incidental finding of a cardiac paraganglioma following ischemic stroke: A case report. [PDF]

Radiol Case Rep
Syed MU, Siddiqui TA, Alam Z, Kottamasu PK, Rosella PA, Reddy B, Rahman AA.   +6 more
europepmc   +1 more source

Engineering a 660 nm‐Responsive Optogenetic Inducer of Pyroptosis for Precision Cancer Therapy

Advanced Science, EarlyView.
This study reports a bioorthogonal pyroptosis inducer, PyroRACS. By using a red‐light‐responsive Cre‐On genetic switch to control the expression of highly cytotoxic GSDMDNT, PyroRACS enables the artificial induction of pyroptosis with precise spatiotemporal control.
Mengkai Zhang, Zhichao Li, Yonghao Ma, Yangyang Sun, Wei Chen, Weiren Huang   +5 more
wiley   +1 more source

Letter to the Editor Nonlinear Associations Between Frailty and Medication Burden in Hospitalized Older Adults. [PDF]

Geriatr Gerontol Int
Goyal K, Kalra R, Nagpal A.
europepmc   +1 more source

Computation and Structure‐Guided Arginine Scanning Engineers a Hyperactive AP Endonuclease for Multiplex Viral RNA Sensing

Advanced Science, EarlyView.
Computational and structure‐guided arginine scanning rewires the DNA‐binding interface of APE1 to create APE1‐Evo, a hyperactive yet specific AP endonuclease. Integrated into the NAPTUNE‐V2.0 cascade, APE1‐Evo enables amplification‐free, multiplex viral RNA sensing for dengue virus and influenza A/B, highlighting a general strategy for engineering ...
Junlan Wang, Ting Wu, Feizuo Wang, Boyang Wang, Xin Yu Wong, Senfeng Zhang, Shengsheng Ma, Yao Liu, Fangyao Yao, Zhifeng Zeng, Siyuan Yang, Kunming Liu, Qi Wang, Yilong Wang, Yunxiang Zang, Xiaolong Wang, Xingxu Huang, Shao Li, Quanquan Ji, Tao Hu, Chunyi Hu   +20 more
wiley   +1 more source

Shifting AAV9 tropism by binding moiety insertion enhances transduction of tumor cell lines and human glioblastoma explants. [PDF]

Sci Rep
Rothschild-Gronau C, Borchert P, Radukic MT, Haverkamp L, Coras R, Simon M, Müller KM.   +6 more
europepmc   +1 more source

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

Advanced Science, EarlyView.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie, Yanbo Zhu, Wenhua Jiang, Haobo Xie, Yaojia Li, Mengjie Hu, Kezheng Li, Huan Yu, Yixuan Pan, Chaoyi Jiang, Xueqin Song, Dongsheng Fan, Binbin Deng   +12 more
wiley   +1 more source

Assessment of Transverse Pavement Texture Homogeneity Under Service-Stage Tire-Induced Uneven Wear Using 3D Laser Scanning. [PDF]

Materials (Basel)
Zheng K, Chen L, Deng W, Lv Q, Leong MI, Wu D.   +5 more
europepmc   +1 more source