Results 221 to 230 of about 570,334 (284)

Engineering Dirac Cones in Graphene for Efficient Iodide Catalysis: Insights by Nanoscale Electrochemistry

open access: yesAdvanced Science, EarlyView.
Graphene iodide oxidation is regulated by Dirac cone engineering. Electrostatic gating tunes the Fermi level to control local iodide oxidation reaction activity, while magic‐angle twisted bilayer graphene creates flat‐band‐derived interfacial states that promote charge transfer and iodine‐species interaction, revealing a nanoscale route to electronic ...
Yang‐Sheng Lu   +13 more
wiley   +1 more source

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

open access: yesAdvanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li   +8 more
wiley   +1 more source

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

open access: yesAdvanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl   +20 more
wiley   +1 more source

A Single‐Amino‐Acid Ligand for LAT1: A Minimalist and Modular Platform for Lysosome‐Targeted Degradation of Membrane Proteins

open access: yesAdvanced Science, EarlyView.
LA‐LYTAC repurposes the cancer‐enriched amino acid transporter LAT1 as a lysosomal trafficking receptor for targeted membrane‐protein degradation. A single phenylalanine‐derived ligand, modularly linked to antibodies or small‐molecule binders, recruits PD‐L1, EGFR, or integrins to LAT1, triggering transporter‐mediated internalization, lysosomal ...
Liquan Zhu   +12 more
wiley   +1 more source

Magnetoelectric Nanoparticles Enable Modulation of Cortical Networks by Low‐Intensity Static Magnetic Fields In Vitro

open access: yesAdvanced Science, EarlyView.
Neuromodulation strategies are increasingly needed to stimulate, restore, or replace altered neuronal activity in disease. Cobalt ferrite‐barium titanate (CFO–BTO) magnetoelectric nanoparticles convert low‐intensity static magnetic fields into local electrical modulation of cortical networks.
Nathalia Cancino‐Fuentes   +13 more
wiley   +1 more source

3D Adversarial Segmentation of Kidney-Transplant Across Multiple MRI Sequences Using Probabilistic and Anatomical Priors. [PDF]

open access: yesDiagnostics (Basel)
Sharaby I   +10 more
europepmc   +1 more source

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