Results 51 to 60 of about 1,699,857 (244)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

open access: yesFEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Two Equivalent Presentations for the Norm of Weighted Spaces of Holomorphic Functions on the Upper Half-plane

open access: yesپژوهش‌های ریاضی, 2019
Introduction In this paper, we intend to show that without any certain growth condition on the weight function, we always able to present a weighted sup-norm on the upper half plane in terms of weighted sup-norm on the unit disc and supremum of ...
ma ardalani
doaj  

Construction of lattice rules for multiple integration based on a weighted discrepancy [PDF]

open access: yes, 2008
High-dimensional integrals arise in a variety of areas, including quantum physics, the physics and chemistry of molecules, statistical mechanics and more recently, in financial applications. In order to approximate multidimensional integrals, one may use
Sinescu, Vasile
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Product of composition and differentiation operators and closures of weighted Bergman spaces in Bloch type spaces

open access: yesJournal of Inequalities and Applications, 2019
Closures of weighted Bergman spaces in Bloch type spaces are investigated in the paper. Moreover, the boundedness and compactness of the product of composition and differentiation operators from Bloch type spaces to closures of weighted Bergman spaces ...
Li-Xu Zhang
doaj   +1 more source

Construction of Good Rank-1 Lattice Rules Based on the Weighted Star Discrepancy [PDF]

open access: yes, 2006
The ‘goodness’ of a set of quadrature points in [0, 1]d may be measured by the weighted star discrepancy. If the weights for the weighted star discrepancy are summable, then we show that for n prime there exist n-point rank-1 lattice rules whose weighted
Joe, Stephen
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

On the Mixed Dirichlet–Steklov-Type and Steklov-Type Biharmonic Problems in Weighted Spaces

open access: yesMathematical and Computational Applications, 2019
We studied the properties of generalized solutions in unbounded domains and the asymptotic behavior of solutions of elliptic boundary value problems at infinity.
Hovik Matevossian
doaj   +1 more source

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