Results 61 to 70 of about 408,881 (273)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Weighted Central BMO Spaces and Their Applications

Journal of Function Spaces, 2021
In this paper, the central BMO spaces with Muckenhoupt Ap weight is introduced. As an application, we characterize these spaces by the boundedness of commutators of Hardy operator and its dual operator on weighted Lebesgue spaces.
Huan Zhao, Zongguang Liu
doaj   +1 more source

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Integral composition operators between weighted Bergman spaces and weighted Bloch type spaces

Cubo, 2012
We characterize boundedness and compactness of integral composition operators acting between weighted Bergman spaces Av,p and weighted Bloch type spaces Bw.Caracterizamos la acotación y compacidad de operadores integrales compuestos actuando entre ...
Elke Wolf
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Weighted Grand Herz-Type Spaces and Its Applications

Journal of Function Spaces, 2022
In this paper, we introduce the weighted grand Herz spaces and weighted grand Herz-type Hardy spaces. The decompositional characterizations of these spaces are established. As its applications, the boundedness of some sublinear operators are established.
Xia Yu, Zongguang Liu
doaj   +1 more source

Approximation in weighted Orlicz spaces

Mathematica Slovaca, 2011
Abstract We prove some direct and converse theorems of trigonometric approximation in weighted Orlicz spaces with weights satisfying so called Muckenhoupt’s A p condition.
Akgün, Ramazan, İsrafilov, Daniyal M.
openaire   +4 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Multipliers of Banach valued weighted function spaces

International Journal of Mathematics and Mathematical Sciences, 2000
We generalize Banach valued spaces to Banach valued weighted function spaces and study the multipliers space of these spaces. We also show the relationship between multipliers and tensor product of Banach valued weighted function spaces.
Serap Öztop
doaj   +1 more source