Results 71 to 80 of about 75,948 (305)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
On approximation in Weighted Orlicz spaces
Mathematica Slovaca, 2011 Abstract An inverse theorem of the trigonometric approximation theory in Weighted Orlicz spaces is proved and the constructive characterization of the generalized Lipschitz classes defined in these spaces is obtained.
Güven, Ali, Israfilov, Daniyal M.
openaire +4 more sources
پژوهشهای ریاضی, 2019 Introduction In this paper, we intend to show that without any certain growth condition on the weight function, we always able to present a weighted sup-norm on the upper half plane in terms of weighted sup-norm on the unit disc and supremum of ...
ma ardalani
doaj
Convolution Algebraic Structures Defined by Hardy-Type Operators
Journal of Function Spaces and Applications, 2013 The main aim of this paper is to show that certain Banach spaces, defined via integral kernel operators, are Banach modules (with respect to some known Banach algebras and convolution products on ℝ+).
Pedro J. Miana +2 more
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Banach Spaces of Analytic Vector-valued Functions [PDF]
, 2007 The main theme of the thesis is the study of continuity and approximation problems, involving matrix-valued and vector-valued Hardy spaces on the unit disc ID and its boundary T in the complex plane.
Barclay, Steven John
core
Integral composition operators between weighted Bergman spaces and weighted Bloch type spaces
Cubo, 2012 We characterize boundedness and compactness of integral composition operators acting between weighted Bergman spaces Av,p and weighted Bloch type spaces Bw.Caracterizamos la acotación y compacidad de operadores integrales compuestos actuando entre ...
Elke Wolf
doaj
Some weighted inequalities for Hausdorff operators and commutators
Journal of Inequalities and Applications, 2018 In this paper, we consider the problem of boundedness of Hausdorff operator on weighted central Morrey spaces. In particular, we obtain sharp bounds for Hausdorff operators on power weighted central Morrey spaces. Analogous results for the commutators of
Amjad Hussain, Amna Ajaib
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source