Results 71 to 80 of about 408,881 (273)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Convolution Algebraic Structures Defined by Hardy-Type Operators

Journal of Function Spaces and Applications, 2013
The main aim of this paper is to show that certain Banach spaces, defined via integral kernel operators, are Banach modules (with respect to some known Banach algebras and convolution products on ℝ+).
Pedro J. Miana, Juan J. Royo, Luis Sánchez-Lajusticia   +2 more
doaj   +1 more source

Some weighted inequalities for Hausdorff operators and commutators

Journal of Inequalities and Applications, 2018
In this paper, we consider the problem of boundedness of Hausdorff operator on weighted central Morrey spaces. In particular, we obtain sharp bounds for Hausdorff operators on power weighted central Morrey spaces. Analogous results for the commutators of
Amjad Hussain, Amna Ajaib
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Two Equivalent Presentations for the Norm of Weighted Spaces of Holomorphic Functions on the Upper Half-plane

پژوهش‌های ریاضی, 2019
Introduction In this paper, we intend to show that without any certain growth condition on the weight function, we always able to present a weighted sup-norm on the upper half plane in terms of weighted sup-norm on the unit disc and supremum of ...
ma ardalani
doaj  

Differences of Composition Operators Followed by Differentiation between Weighted Banach Spaces of Holomorphic Functions

Abstract and Applied Analysis, 2013
We characterize the boundedness and compactness of differences of the composition operators followed by differentiation between weighted Banach spaces of holomorphic functions in the unit disk.
Cui Chen, Ren-Yu Chen, Ze-Hua Zhou
doaj   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

On Variable Exponent Amalgam Spaces

Analele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2012
We derive some of the basic properties of weighted variable exponent Lebesgue spaces Lp(.)w (ℝn) and investigate embeddings of these spaces under some conditions.
Aydin İsmail
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Norms of Composition Operators from Weighted Harmonic Bloch Spaces into Weighted Harmonic Zygmund Spaces

Journal of Function Spaces
This article examines the norms of composition operators from the weighted harmonic Bloch space BHλ ...
Munirah Aljuaid, M. A. Bakhit
doaj   +1 more source