Results 71 to 80 of about 21,411 (263)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Moderate deviations and Erdös–Rényi–Shepp laws for weighted sums
, 2003 Let X0,X1,… be i.i.d. random variables with E(X0)=0, E(X20)=1 and E(exp{tX0})
Gao, Fuqing
core +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
On sums of weighted averages of $\gcd$-sum functions
, 2018 Let $\gcd(j,k)$ be the greatest common divisor of the integers $j$ and $k$. In this paper, we give several interesting asymptotic formulas for weighted averages of the $\gcd$-sum function $f(\gcd(j,k)) $ and the function $\sum_{d|k, d^{s}|j}(f*μ)(d) $ for any positive integers $j$ and $k$, namely $$ \sum_{k\leq x}\frac{1}{k^{r+1}}\sum_{j=1}^{k}j^{r}f ...
Kiuchi, Isao, Eddin, Sumaia Saad
openaire +2 more sources
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Construction of lattice rules for multiple integration based on a weighted discrepancy
, 2008 High-dimensional integrals arise in a variety of areas, including quantum physics, the physics and chemistry of molecules, statistical mechanics and more recently, in financial applications. In order to approximate multidimensional integrals, one may use
Sinescu, Vasile
core
Strong stability of weighted sums of NA random variables [PDF]
, 2004 We study the almost sure (strong) stability of weighted sums of NA random variables and obtain some new results which extend earlier results of Matula (1992), Chow and Teicher (1971), Jamison et al. (1965), and Petrov (1975)
Gan Shixin
core +1 more source