Results 51 to 60 of about 9,298,099 (293)
FEBS Open Bio, EarlyView.Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty +13 more
wiley +1 more source
Weighted sparsity and sparse tensor networks for least squares approximation [PDF]
, 2023 The approximation of high-dimensional functions is a ubiquitous problem in many scientific fields that is only feasible practically if advantageous structural properties can be exploited. One prominent structure is sparsity relatively to some basis.
Trunschke, Philipp +2 more
core +1 more source
, 2010 Recent advances in total least squares approaches for solving various errors-in-variables modeling problems are reviewed, with emphasis on the following generalizations: 1.
Markovsky, Ivan +2 more
core +1 more source
Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank
FEBS Open Bio, EarlyView.Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer +7 more
wiley +1 more source
A minimal cellulosome‐like system in Cellulosilyticum lentocellum
FEBS Open Bio, EarlyView.Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan +2 more
wiley +1 more source
Least squares fitting the three-parameter inverse Weibull density [PDF]
, 2010 The inverse Weibull model was developed by Erto [10]. In practice, the unknown parameters of the appropriate inverse Weibull density are not known and must be estimated from a random sample.
Marušić, Miljenko +5 more
core +1 more source
On the computation of the structured total least squares estimator
, 2004 A class of structured total least squares problems is considered, in which the extended data matrix is partitioned into blocks and each of the blocks is (block) Toeplitz/Hankel structured, unstructured, or noise free.
Van Huffel, S. +2 more
core +1 more source
On the complex least squares problem with constrained phase [PDF]
, 2011 The problem of solving approximately in the least squares sense an overdetermined linear system of equations with complex valued coefficients is considered, where the elements of the solution vector are constrained to have the same phase.
Markovsky, Ivan
core +2 more sources
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Least-squares methods for identifying biochemical regulatory networks from noisy measurements [PDF]
, 2007 <b>Background</b>: We consider the problem of identifying the dynamic interactions in biochemical networks from noisy experimental data.
Postlethwaite, I. +23 more
core +1 more source