Results 61 to 70 of about 525,476 (324)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Anomalous Zenith Total Delays for an Insular Tropical Location: The Tahiti Island Case
Remote Sensing, 2022 The weighted mean temperature of the troposphere, Tm, is a key parameter in GNSS meteorology. It can be routinely derived based on meteorological data from radiosonde (RS) or numerical weather models. Alternatively, it can be also derived through a least-
Fangzhao Zhang +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
Total least-squares EIO model, algorithms and applications
Geodesy and Geodynamics, 2019 A functional model named EIO (Errors-In-Observations) is proposed for general TLS (total least-squares) adjustment. The EIO model only considers the correction of the observation vector, but doesn't consider to correct all elements in the design matrix ...
Xingsheng Deng +3 more
doaj +1 more source
Spatial variation of total column ozone on a global scale
, 2007 The spatial dependence of total column ozone varies strongly with latitude, so that homogeneous models (invariant to all rotations) are clearly unsuitable.
Stein, Michael L.
core +2 more sources
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
Molecules, 2018 Background: Pu-erh tea is a unique microbially fermented tea, which distinctive chemical constituents and activities are worthy of systematic study. Near infrared spectroscopy (NIR) coupled with suitable chemometrics approaches can rapidly and accurately
Ze Liu +3 more
doaj +1 more source
Convex Total Least Squares [PDF]
, 2014 We study the total least squares (TLS) problem that generalizes least squares regression by allowing measurement errors in both dependent and independent variables. TLS is widely used in applied fields including computer vision, system identification and
Malioutov, Dmitry M., Slavov, Nikolai
core +1 more source