Results 111 to 120 of about 1,216,959 (343)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Weighting of items in a tutorial performance evaluation instrument: Statistical analysis and results
Health SA Gesondheid: Journal of Interdisciplinary Health Sciences, 2009 Weighting of items in an evaluation instrument contributes to more meaningful and valid interpretations of student performance in respect of each learning outcome or item being assessed.
Melanie L. Lack +2 more
doaj +1 more source
Weighted Fuzzy Clustering Algorithm Based on Dynamic Interval
Jisuanji kexue yu tansuo, 2020 Clustering is widely used in data mining and data analysis, and a great many of troubles have been caused by incomplete data in clustering. Aiming at the inaccurate problem of filling missing attributes with estimation method in incomplete data ...
LUO Hao, WANG Yanjie, NIU Minghang, QIU Cunyue, ZHANG Li
doaj +1 more source
Time weighted portfolio optimisation [PDF]
, 2001 In estimating the inputs into the Modern Portfolio Theory (MPT) portfolio optimisation problem, it is usual to use equal weighted historic data.
Lee, Stephen
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Information Dissipation in Random Quantum Networks
, 2014 We study the information dynamics in a network of spin-$1/2$ particles when edges representing $XY$ interactions are randomly added to a disconnected graph accordingly to a probability distribution characterized by a "weighting" parameter. In this way we
Farooq, Umer, Mancini, Stefano
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Hybrid Similarity Measure in SmartLP: A Case Based System in Lesson Planning
Journal of ICT in Education, 2019 Planning for teaching imposes a significant burden on teachers as they need to prepare different lesson plans for different classes according to various constraints such as students’ ability and previous knowledge.
Aslina Saad +2 more
doaj
Guidelines for Weighting Factors Adjustment in Finite State Model Predictive Control of Power Converters and Drives [PDF]
, 2009 INTERNATIONAL CONFERENCE ON INDUSTRIAL TECHNOLOGY () (.2009.VICTORIA, AUSTRALIA)Model Predictive Control with a finite control set has emerged as a promising control tool for power converters and drives.
Cortés, Patricio +7 more
core
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source