Results 41 to 50 of about 1,076,501 (310)

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

Modeling and Simulation of a Screw-Worm Gear Mechanical Transmission to Achieve its Optimal Design under Imposed Constraints

open access: yesJournal of Algorithms & Computational Technology, 2011
This work deals with the modeling and simulation of a screw-worm gear mechanical transmission (worm gear screw jack), abbreviated WGSJ, to achieve its optimal design under imposed constraints.
Claudiu V. Suciu   +2 more
doaj   +1 more source

Generalizations of the clustering coefficient to weighted complex networks [PDF]

open access: yesPhysical Review E, 2007
4 pages, 1 table, 3 figures; revised ...
Saramaki, J.   +4 more
openaire   +3 more sources

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Multi-method joint monitoring study on strata behavior in shallow seam mining under bedrock gully

open access: yesScientific Reports, 2023
The Baijigou Coal Mine in Helan mountain mining area is alpine gully landform, and the double key stratums are cut by the gully. A two-dimensional physical similarity model under this condition was established in the laboratory.
Jing Chai   +5 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Examination of the effect of array weighting function on radar target detectability [PDF]

open access: yes, 2010
This paper describes a methodology to assess the detectability of targets by anairborne fire control radar operating in a medium PRF mode in the presence of strongground clutter as a function of the transmitting and receiving antenna array ...
Alabaster, Clive M.   +3 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Extending weighting models with a term quality measure [PDF]

open access: yes, 2007
Weighting models use lexical statistics, such as term frequencies, to derive term weights, which are used to estimate the relevance of a document to a query.
Ounis, I.   +3 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

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