Results 101 to 110 of about 154,350 (268)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Cascaded Finite State Control for a Five-Phase Induction Machine
Applied SciencesThe area of Finite State Model Predictive Control (FSMPC) has seen a rapid development in recent years. In particular, its application to multiphase induction machine drives has received attention due to the specific advantages of such systems. The FSMPC
Manuel R. Arahal +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
A REMARK ON WEIGHTED REPRESENTATION FUNCTIONS
Taiwanese Journal of Mathematics, 2014 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +2 more sources
Hybrid Weighting Strategy for Multi-Loss- Function of Aesthetics Aware GAN
IEEE AccessGenerative Adversarial Networks (GANs) have been widely extended with multiple loss functions to encourage the generation of images with desirable properties beyond realism, such as compositional balance and color aesthetics.
Yaya Setiyadi +2 more
doaj +1 more source
A NOVEL TERM WEIGHTING SCHEME MIDF FOR TEXT CATEGORIZATION [PDF]
Journal of Engineering Science and Technology, 2010 Text categorization is a task of automatically assigning documents to a set of predefined categories. Usually it involves a document representation method and term weighting scheme.
C. DEISY +4 more
doaj
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
FCS-MPC Based on Dimension Unification Cost Function
EnergiesFinite Control Set Model Predictive Control (FCS-MPC) has the ability to achieve multi-objective optimization, but there are still many challenges. The key to realizing multi-objective optimization in FCS-MPC lies in the design of the cost function ...
Jinyang Han +5 more
doaj +1 more source