Results 51 to 60 of about 20,184 (348)

The Case for Bisphosphonate Use in Astronauts Flying Long-Duration Missions

Cells
Changes in the structure of bone can occur in space as an adaptive response to microgravity and on Earth due to the adaptive effects to exercise, to the aging of bone cells, or to prolonged disuse.
Reece Rosenthal, Victor S. Schneider, Jeffrey A. Jones, Jean D. Sibonga   +3 more
doaj   +1 more source

Separator Patent [PDF]

, 1966
Liquid-gaseous centrifugal separator for weightlessness ...
Booth, F. W.
core   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Gravity influences top-down signals in visual processing. [PDF]

PLoS ONE, 2014
Visual perception is not only based on incoming visual signals but also on information about a multimodal reference frame that incorporates vestibulo-proprioceptive input and motor signals.
Guy Cheron, Axelle Leroy, Ernesto Palmero-Soler, Caty De Saedeleer, Ana Bengoetxea, Ana-Maria Cebolla, Manuel Vidal, Bernard Dan, Alain Berthoz, Joseph McIntyre   +9 more
doaj   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

Simulated weightlessness procedure, head-down bed rest impairs adult neurogenesis in the hippocampus of rhesus macaque

Molecular Brain, 2019
The microgravity environment in space can impact astronauts’ cognitive and behavioral activities. However, due to the limitations of research conditions, studies of biological changes in the primate brain, such as neurogenesis, have been comparatively ...
Xu Zhang, Xixia Chu, Lei Chen, Juan Fu, Shuai Wang, Jinjing Song, Guanghan Kan, Weizhong Jiang, Guang He, Xiaoping Chen, Weidong Li   +10 more
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Artificial gravity as a countermeasure for mitigating physiological deconditioning during long-duration space missions

Frontiers in Systems Neuroscience, 2015
In spite of the experience gained in human space flight since Yuri Gagarin’s historical flight in 1961, there has yet to be identified a completely effective countermeasure for mitigating the effects of weightlessness on humans. Were astronauts to embark
Gilles eClement, Angie eBukley, William ePaloski   +2 more
doaj   +1 more source

Recent results from zero g cargo handling studies [PDF]

, 1971
Cargo handling, transfer, and stowage under weightlessness conditions of space ...
Beasley, G. P.
core   +1 more source