Results 81 to 90 of about 17,802 (285)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Weightlessness and skeleton homeostasis
HORMONES, 2005 As human beings venture into space in the 21st century, they will be confronted with a "hypodynamic" and thus hostile environment for the bone homeostasis, that could potentially compromise their mobility in general and skeletal strength in particular after landing. From this point of view, space flight studies are especially interesting and intriguing
Konstantinos, Ziambaras +2 more
openaire +2 more sources
Alterations in gut transport of minerals and in binding proteins during simulated weightlessness [PDF]
The structural components of the skeleton develop and are maintained in a 1 g environment, shaped by the mechanical load to which they are constantly exposed.
Bikle, D. D.
core +1 more source
Space vehicle with artificial gravity and earth-like environment [PDF]
, 1973 A space vehicle adapted to provide an artificial gravity and earthlike atmospheric environment for occupants is disclosed. The vehicle comprises a cylindrically shaped, hollow pressure-tight body, one end of which is tapered from the largest diameter of ...
Gray, V. H.
core +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Orientation in Aerospace Flight [PDF]
Spatial orientation and weightlessness problems in manned space ...
Graybiel, A.
core +1 more source
Getaway Special competition: Overview [PDF]
, 1984 Recommendations submitted for experiments to be conducted onboard the space shuttle are presented.
Trump, C. G.
core +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Skeletal stressing method and apparatus Patent [PDF]
, 1970 Method and apparatus for applying compressional forces to skeletal structure of subject to simulate force during ambulatory ...
Howard, W. H., Young, D. R.
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source