Results 101 to 110 of about 3,134,168 (295)

Deservingness Transfers [PDF]

, 2020
This article seeks to cause trouble for a brand of consequentialism known as ‘desertarianism’. In somewhat different ways, views of this kind evaluate outcomes more favourably, other things equal, the better the fit between the welfare different people ...
Skarsaune, Knut Olav
core  

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Evaluating Electricity Demand Elasticity From a Social Perspective: Implications for Sustainable Development and Urban Resilience

IEEE Access
The central focus of this study revolves around constructing a comprehensive load model to estimate the elasticity of electricity demand predicated on customers’ risk-averse tendencies.
Yaser A. Nanehkaran, Shixi Tang, Amir Bairami Akhi Jahani, Amir Niromandfam, Tolga Pusatli   +4 more
doaj   +1 more source

Aboriginal Child Welfare [PDF]

, 2003
As the relationships between Canada’s Aboriginal peoples and the state undergo changes, the issue of Child Welfare is in the foreground; for it is around the well being, education and care of Aboriginal children that much of the painful historical ...
Blackstock, Cindy, Carlson, J. Clouston, Fine, Marshall, Mandell, Deena   +3 more
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Italians Can Resist Everything, Except Flat-Faced Dogs!

Animals
Brachycephalic dogs remain highly popular despite the well-documented health problems associated with their conformation. The aim of this study was to investigate differences in the bonding between humans and dogs, behavioral characteristics, awareness ...
Simona Cannas, Clara Palestrini, Sara Boero, Alice Garegnani, Silvia M. Mazzola, Emanuela Prato-Previde, Greta V. Berteselli   +6 more
doaj   +1 more source

Using Intermediary Structures to Support Families: An International Comparison of Practice in Child Protection [PDF]

, 2001
Responses to child maltreatment can be conceptualized as a continuum, ranging from a welfare-oriented approach on one end, to a legalistic emphasis at the other end.
Freymond, Nancy Colleen
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Pilot Study: Simultaneous Daily Recording of Total Locomotor Activity and Heart Rate in Horses for Application in Precision Livestock Farming

Animals
Among physiological parameters, total locomotor activity (TLA) and heart rate (HR) are used as physiological indicators in animal welfare evaluations.
Francesca Aragona, Maria Rizzo, Federica Arrigo, Francesca Arfuso, Francesco Fazio, Elisabetta Giudice, Pietro Pugliatti, Giuseppe Piccione, Claudia Giannetto   +8 more
doaj   +1 more source