Results 101 to 110 of about 3,527,904 (336)

Guidelines for the welfare and use of animals in cancer research

British Journal of Cancer, 2010
Animal experiments remain essential to understand the fundamental mechanisms underpinning malignancy and to discover improved methods to prevent, diagnose and treat cancer.
P. Workman, E. Aboagye, F. Balkwill, A. Balmain, G. Bruder, D. Chaplin, J. Double, J. Everitt, D. Farningham, D. Farningham, M. Glennie, L. Kelland, V. Robinson, I. Stratford, G. Tozer, S. Watson, S. Wedge, S. Eccles, V. Navaratnam, S. Ryder   +19 more
semanticscholar   +1 more source

\ud Strategic Social Marketing for Expanding the Commercial Market of Insecticide Treated Nets in Tanzania\ud [PDF]

, 2007
\ud The Department for International Development (DfID) has been supporting the introduction of ITNs in Tanzania since January 1998. The social marketing of ITNs for malaria prevention in Tanzania was introduced at a national scale in 2000 through the ...
Ministry of Health and Social Welfare, (MoHSW)
core  

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Community Engagement, Child Welfare, and Domestic Violence Service Agencies

International Journal of Child, Youth & Family Studies, 2010
Although coordinated community responses to domestic violence are widely encouraged in the literature as a best practice approach, collaboration between multiple domestic violence response service agencies and government systems is often not achieved ...
Colleen MacPherson
doaj   +1 more source

Citizens, consumers and farm animal welfare: A meta-analysis of willingness-to-pay studies

, 2017
The sustainable intensification of animal production systems is increasing as a consequence of increased demand for foods originating from animals. Production diseases are particularly endemic in intensive production systems, and can negatively impact ...
B. Clark, G. Stewart, L. Panzone, I. Kyriazakis, L. Frewer   +4 more
semanticscholar   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Why We Need A New Welfare State

, 2002
Contributors to this volume - Frank Vandenbrucke (Belgian Minister for Social Affairs) Gosta Esping Andersen, Professor of Sociology at Universidad Pompeu Fabra, Barcelona, Spain Duncan Gallie, Nuffield Collage, University of Oxford Anton Hemerijck ...
G. Esping-Andersen
semanticscholar   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source