Results 71 to 80 of about 1,159,902 (301)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
The performance of farm animal assessment
, 2011 This paper argues that the current drive towards greater use of animal-based measures for welfare assessment raises important issues for how farm visits by welfare assessors are performed.
Bull, J., Buller, H., Roe, E.
core
Communication in animal health and welfare planning [PDF]
, 2008 The project ‘Minimising medicine use in organic dairy herds through animal health and welfare promotion’ is focused on animal welfare assessment and its role in the active use of animal health plans in order to improve animal health and welfare on ...
Smolders, Gidi +2 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
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Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
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Infectious Diseases and TherapyIntroduction Respiratory syncytial virus (RSV) is a common cause of lower respiratory tract disease, and the standard prevention strategy in Japan is limited to high-risk infants.
Shinichi Noto +7 more
doaj +1 more source
International Journal of Public Administration, Management and Economic Development, 2023 This research paper examines the interconnections between culture, education, and welfare in Vietnam. Scholarly works by Jan Vrba, Huynh, Kien, and Hue provide insights into Vietnam's welfare system and its challenges. The paper recommends strengthening cultural and educational integration, investing in technology, enhancing social protection systems ...
openaire +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Animals, 2020 Knowledge of the welfare status of wild animals is vital for informing debates about the ways in which we interact with wild animals and their habitats.
Andrea M. Harvey +3 more
doaj +1 more source