Results 81 to 90 of about 1,159,902 (301)

Priority for the Worse Off and the Social Cost of Carbon [PDF]

, 2016
The social cost of carbon (SCC) is a monetary measure of the harms from carbon emission. Specifically, it is the reduction in current consumption that produces a loss in social welfare equivalent to that caused by the emission of a ton of CO2.
A Millner, A Williams, AC Pigou, B Tungodden, C Blackorby, C Brown, C Gollier, C Kolstad, D Anthoff, D Parfit, D Parfit, DM Kreps, EA Stanton, F Dennig, FA Cowell, FHG Ferreira, FP Ramsey, GG Szpiro, J Broome, J Broome, J Cockburn, J Quiggin, J Rawls, JA Mirrlees, JA Weymark, JCJM van den Bergh, JCJM van den Bergh, KJ Arrow, L Kaplow, LG Epstein, M Drupp, M Fleurbaey, M Greenstone, MD Adler, MD Adler, MD Adler, MK Brunnermeier, ML Weitzman, N Holtug, N Holtug, N Stern, N Stern, O Johansson-Stenman, OP Attanasio, P Dasgupta, P-A Chiappori, PA Samuelson, R Boadway, R Chetty, RF Harrod, RM Solow, RS Pindyck, RS Tol, RW Boadway, S Anand, S Dietz, T Porter, W Bossert, W Pizer, WD Nordhaus, WD Nordhaus, WD Nordhaus, WD Nordhaus, WJW Botzen   +63 more
core   +4 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Model to evaluate welfare in dairy cow farms

Italian Journal of Animal Science, 2010
The assessment of herd welfare is a scientific discipline that is rapidly developing. The scientific community plays an important role in delivering appropriate, repeatable, valid and feasible models for this assessment.
Luigi Calamari, Giuseppe Bertoni
doaj   +1 more source

Impacts of labour on interactions between economics and animal welfare in extensive sheep farms [PDF]

This study quantified interactions between animal welfare and farm profitability in British extensive sheep farming systems. Qualitative welfare assessment methodology was used to assess welfare from the animal's perspective in 20 commercial extensive ...
Dwyer, Cathy M., Erhard, H.W., Goddard, Pete, Kupiec-Teahan, Beata, Milne, Catherine E., Morgan-Davies, Claire, Phillips, Kate, Ringrose, Sian, Stott, Alistair W., Vosough Ahmadi, Bouda, Waterhouse, A.   +10 more
core   +1 more source

The CIA on Canadian Defence Policy [PDF]

, 2020
At the request of the Pentagon, in the spring of 1985 the Central Intelligence Agency prepared an assessment of Canadian defence policy. Brian Mulroney’s Progressive Conservatives had formed the government in the election of 4 September 1984 and, in the ...
Granatstein, J.L.
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Tactile, Auditory, and Visual Stimulation as Sensory Enrichment for Dairy Cattle

Animals
Several types of enrichment can be used to improve animal welfare. This review summarizes the literature on the use of mechanical brushes, tactile udder stimulation, music, and visual stimuli as enrichment methods for dairy cows.
Daniel Mota-Rojas, Alexandra L. Whittaker, Adriana Domínguez-Oliva, Ana C. Strappini, Adolfo Álvarez-Macías, Patricia Mora-Medina, Marcelo Ghezzi, Pamela Lendez, Karina Lezama-García, Temple Grandin   +9 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Human animal relationships in Bos indicus cattle breeds addressed from a Five Domains welfare framework

Frontiers in Veterinary Science
The present review has two objectives, the first is to investigate the differences in temperament between Bos indicus and Bos taurus breeds and determining the effects on production due to positive treatment and to compare this with negative HAR, by ...
Daniel Mota-Rojas, Alexandra L. Whittaker, Ana C. Strappini, Agustín Orihuela, Adriana Domínguez-Oliva, Patricia Mora-Medina, Adolfo Álvarez-Macías, Ismael Hernández-Avalos, Adriana Olmos-Hernández, Brenda Reyes-Sotelo, Temple Grandin   +10 more
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source