Results 31 to 40 of about 21,649,356 (288)
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
, 1960 These biennial reports are summaries of the activities of this agency. They were extracted from a series of Kansas agency reports covering over 100 state agencies and institutions bound together for each biennium, 1959/1960 - 1979/1980.
Kansas. State Department of Social Welfare.
core +1 more source
Current State of Cholera Specific Prophylaxis
Эпидемиология и вакцинопрофилактика, 2018 The threat of cholera spread beyond the borders of endemic countries and the realness of the emergence of introduced epidemic foci remain the actual problems and neccessitate continuous development of specific prophylaxis of this disease.
I. A. Bespalova +4 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
SSRN Electronic Journal, 2010 AbstractThe chapter compares employment structures in five Continental European welfare states, with a focus on private services. Despite a common trend to overcome institutional employment barriers by creating a more divided labor market, a closer look reveals considerable differences between national patterns of standard and non-standard work.
Eichhorst, Werner, Marx, Paul
openaire +4 more sources
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Welfare Service Professionals, Migrants, and the Question of Trust. A Danish Case
Professions and Professionalism, 2016 The aim of this article is to analyze migrants’ interpretations of their encounters with welfare service professionals in Denmark, focusing on client trust and exploring its diversity across professions.
Barbara Fersch
doaj +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Social work and welfare system Commonalities and differences between Portugal, Spain and Germany
Serviço Social em Revista, 2011 The development of the welfare state intersects with the knowledge and the Social Action. Specialists in this area argue that knowledge and action are associated with Social Service to the type of welfare state pursued in each country.
Maria Irene Carvalho
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Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source