Results 91 to 100 of about 1,097,065 (304)

Transaction Costs, Information Technology and Development [PDF]

This paper examines the impact of transaction costs on economic welfare and development. We extend the static model of Romer (1994), in which transaction costs reduce welfare by the reducing the equilibrium number of intermediate goods, and estimate the ...
Singh, Nirvikar
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Use of high concentrations of carbon dioxide for stunning rabbits reared for meat production

World Rabbit Science, 2016
: An investigation was performed to determine whether high concentrations of carbon dioxide (CO2) at 70-98% in atmospheric air are a suitable alternative for stunning rabbits compared to conventional approaches such as electronarcosis.
A. Dalmau, J. Pallisera, C. Pedernera, I. Muñoz, R. Carreras, N. Casal, E. Mainau, P. Rodriguez, A. Velarde   +8 more
doaj   +1 more source

Tradeoff between Inflation Stabilization and Growth Maximization [PDF]

This paper analyzes monetary policy implication in an endogenous growth model in which the average growth rate is inefficiently low and in which the capital accumulation technology is concave. This paper does two exercises.
Hiroki Arato
core  

The Corporate Welfare State: How the Federal Government Subsidizes U.S. Businesses [PDF]

, 2007
The federal government spent $92 billion in direct and indirect subsidies to businesses and private- sector corporate entities -- expenditures commonly referred to as "corporate welfare" -- in fiscal year 2006.
Stephen Slivinski
core  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Welfare technology interventions among older people living at home-A systematic review of RCT studies. [PDF]

PLOS Digit Health, 2023
Pajalic Z, de Sousa DA, Strøm BS, Lausund H, Breievne G, Kisa S, Saplacan D, Larsen MH, Jøranson N.   +8 more
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

RETHINKING SOLIDARITY THROUGH WELFARE TECHNOLOGY FOR OLDER ADULTS

Banber Erevani Hamalsarani. Sots'iologia
The welfare state is under pressure. Demographic changes, high expectations for services, and limited resources demand new approaches to service provision.
Brita Gjerstad, Inger Lise Teig
doaj   +1 more source

Inappropriate Technology [PDF]

In this paper, we investigate incentives other than altruism that developed countries have in improving technologies specific to developing countries.
Ana Fernandes, Krishna B. Kumar
core