Results 81 to 90 of about 230,838 (295)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Proactive health and welfare technology for Nordic users and societies – A policy brief [PDF]
, 2023 This policy brief addresses the challenges and knowledge needs related to health and welfare technology use. It is particularly focused on Nordic countries because the research work was conducted there.
Rødseth, Eirin +10 more
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
new politics of welfare reform in post-communist Europe
, 2005 Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Political Science, 2005.Vita.Includes bibliographical references (p. 296-304).This dissertation explores the evolution of welfare systems in post-socialist countries.
Brown, Dana L., Ph. D. Massachusetts Institute of Technology
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Vertical technology transfer and the implications of patent protection [PDF]
Significant amount of vertical technology transfer occurs between developed and developing country firms, yet the literature on intellectual property rights did not pay much attention to this aspect.
Chiranjib Neogi, Arijit Mukherjee
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A System Dynamics Model to Investigate Welfare Loss of Environmental Pollution in Iran [PDF]
پژوهشهای اقتصادی, 2015 This article analyzes the welfare loss of pollution resulting from production in Iranian economy using an augmented growth model and designing an economic-ecological system dynamics model.
javad harati +3 more
doaj
Welfare Technology Policy and Practice - A Conceptual Analysis
2019 IEEE International Conference on Industrial Engineering and Engineering Management (IEEM), 2019 This exploratory study identifies two existing conceptions of welfare technology identified from policy and practice. By using policy documents and previous research together with a survey of primary care managers and students, this paper identifies one wider and one narrower conception. The wider tends to include the whole society, making it difficult
openaire +3 more sources
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Design Thinking and Welfare Technology: A Focus on Information Design [PDF]
, 2022 Digitalization has transformed the ways in which people interact, communicate, work and study. In social and healthcare services, in line with this transformation, the use of welfare technology is increasing.
Melkas, Helinä +3 more
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