Results 91 to 100 of about 230,838 (295)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Liberalisasi Pertanian Versus Kesejahteraan Petani: Upaya Mencari Jalan Tengah

Jurnal Pamator, 2019
Agricultural liberalization continued controversy. Intensification of agriculture industry in Indonesia has not been able to welfare of farmers. Thus, the application of agricultural technology is always faced to the welfare of farmers.
Achmad Faidy Suja’ie, Nian Riawati
doaj   +1 more source

Welfare Technologies and Ageing Bodies: Various Ways of Practising Autonomy [PDF]

Rehabilitation Research and Practice, 2018
Contemporary policy strategies frame welfare technologies as a solution for welfare states facing the challenges of demographic change. Technologies are supposed to reduce or substitute the work of care workers and thereby reduce attrition among their ranks, reduce costs, and at the same make elderly people self-reliant and independent.
openaire   +3 more sources

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Child Welfare and Technology (CW360°)

, 2011
Child Welfare 360° (CW360°) is an annual publication that provides communities, child welfare professionals, and other human service professionals, comprehensive information on the latest research, policies and practices in a key area affecting child ...

core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Transfer of Pollution Abatement Technology and Unemployment [PDF]

This paper investigates the effects of the transfer of pollution abatement technology on the level of urban unemployment, the total amount of pollution, and social welfare in a small, open Harris Todaro economy.
Muneyuki Saito, Yasuyuki Sugiyama
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Use of high concentrations of carbon dioxide for stunning rabbits reared for meat production

World Rabbit Science, 2016
: An investigation was performed to determine whether high concentrations of carbon dioxide (CO2) at 70-98% in atmospheric air are a suitable alternative for stunning rabbits compared to conventional approaches such as electronarcosis.
A. Dalmau, J. Pallisera, C. Pedernera, I. Muñoz, R. Carreras, N. Casal, E. Mainau, P. Rodriguez, A. Velarde   +8 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Welfare Transitions in the 1990s: The Economy, Welfare Policy, and the EITC [PDF]

The rapid decline in the welfare caseload remains a subject of keen interest to both policymakers and researchers. In this paper, I use data from the Survey of Income and Program Participation spanning the period from 1986 to 1999 to analyze how the ...
Jeffrey Grogger
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