Results 71 to 80 of about 3,287,588 (278)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Typification of the deposits of the Tyumen Formation according to the degree of hydrodynamic conditions of sedimentation to create a petrophysical model and differentiated interpretation of well log data

Georesursy
The article considers facies analysis and the application of its results for the typification of rocks of the Tyumen Formation. The aim of the article is to create algorithms for the differentiated interpretation of geophysical studies of well log data ...
T. G. Isakova, A. S. Persidskaya, O. V. Khotylev, J. A. Kotochkova, A. D. Egorova, T. F. Dyakonova, A. S. Mozgovoy, V. V. Churkina, S. V. Kozakov, N. V. Kozhevnikova, R. Z. Livaev, V. S. Druchin, N. V. Belov, G. A. Kalmykov   +13 more
doaj   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Simulating elastic wave propagation in boreholes: Fundamentals of seismic response and quantitative interpretation of well log data

Geofísica Internacional, 2011
Se presenta una formulación analítica orientada al entendimiento de la difracción, dispersión y atenuación de los modos de propagación en pozo.
Rafael Ávila-Carrera, James H. Spurlin, Celestino Valle-Molina   +2 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Absence of Evidence Is Not Evidence of Absence: The Color-Density Relation at Fixed Stellar Mass Persists to z ~ 1

, 2010
We use data drawn from the DEEP2 Galaxy Redshift Survey to investigate the relationship between local galaxy density, stellar mass, and rest-frame galaxy color.
Alison L. Coil, Baldry, Bell, Bell, Benjamin J. Weiner, Blanton, Brian F. Gerke, Bundy, Bundy, Capak, Christopher J. Conselice, Christopher N. A. Willmer, Coil, Coil, Coil, Coil, Conselice, Cooper, Cooper, Cooper, Cooper, Cucciati, Darren J. Croton, David C. Koo, Efron, Elbaz, Foucaud, Gerke, Gerke, Hodges, Hogg, Ilbert, Jeffrey A. Newman, Kauffmann, Kevin Bundy, Knobel, Kovac, Le Fèvre, Le Fèvre, Lihwai Lin, Lilly, Lin, Maltby, Mann, Marc Davis, Meneux, Michael C. Cooper, Pannella, Patel, Puragra Guhathakurta, Renbin Yan, Rettura, S. M. Faber, Scodeggio, Tasca, Van Der Wel, Van Der Wel, Wall, Willmer   +58 more
core   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Machine Learning-Based Prediction of Subsurface Elastic Properties Using Seismic and Well-Log Data

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
The elastic properties of subsurface media, such as density and P- and S-wave velocity, are essential for understanding the mechanical behavior of the subsurface as they reflect its physical and structural characteristics. Accurate elastic properties are
Sujeong Kim, Yongchae Cho, Yongsik Gihm, Hyunggu Jun   +3 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source