Results 31 to 40 of about 15,623,747 (237)
Energies, 2022 Aimed at the development of shale gas reservoirs with large reservoir thickness and multiple layers, this paper carried out a numerical simulation study on the optimization of three different well types: horizontal well, deviated well, and vertical well.
Tao Huang +4 more
doaj +1 more source
Non-Linear Programming for Well Spacing Optimization of Oil Reservoirs.
, 2010 Background: The subject of well spacing is one of vital importance in the petroleum industry. The well itself plays a very significant role in the development of the oil and gas reservoirs and in the control of the recovery process.
U. M. John, M. O. Onyekonwu
core +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Youqicang pingjia yu kaifa, 2021 The design of shale gas well spacing is the key to the technical policy of gas field development, which is related to the maximum utilization of resources.
ZHAO Yong +3 more
doaj
A method for generating a well-distributed Pareto set in nonlinear multiobjective optimization [PDF]
, 2009 A method is presented for generating a well-distributed Pareto set in nonlinear multiobjective optimization. The approach shares conceptual similarity with the Physical Programming-based method, the Normal-Boundary Intersection and the Normal ...
Utyuzhnikov, S.V.; id_orcid +7 more
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
地质科技通报With the implementation of infilling new wells and refracturing existing ones, the spacing between wells has decreased, the scale of stimulation for individual wells has expanded, and the level of interference among wells has heightened, significantly ...
Jiawei REN +5 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source