Results 41 to 50 of about 15,623,747 (237)
Influencing factors and prevention optimization of shallow shale gas inter-well frac-hits
Shiyou shiyan dizhiThe Zhaotong shallow shale gas field is the first pilot demonstration area in China for medium to shallow shale gas development, with main burial depths ranging from 1 000 to 2 200 m.
Ming JIANG +5 more
doaj +1 more source
Text spacing considerations for children’s on-screen reading [PDF]
, 2008 This investigation seeks to uncover the insights of three integral and inter-related participants in the creation and use of on-screen reading material for children’s learning.
Vanderschantz, Nicholas +1 more
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Energies, 2019 A data-driven workflow approach is presented in this study for optimizing fracture spacing of multifractured horizontal wells (MFHW) in shale oil reservoirs.
Xu Yang, Boyun Guo
doaj +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Petroleum ResearchGulong shale has abundant oil resources with low-porosity and low-permeability reservoir characteristics, and effective development has been achieved using horizontal well volume fracturing in single-well network deployment.
Lifeng Liu +4 more
doaj +1 more source
Optimization of positional parameters of close-formation flight for blended-wing-body configuration
Heliyon, 2018 In the present study, we study formation flight with two flying wing configurations. A low speed wind tunnel test is conducted to validate the accuracy of the Computational Fluid Dynamics (CFD).
Tao Yang +4 more
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source