Results 61 to 70 of about 106,969 (295)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Présentation des hebdomadaires de langue galloise

La Bretagne Linguistique, 1992
This paper will provide a brief overview of the historical development of Welsh and its current situation. After an analysis of the sociolinguistic history of Welsh over the last half millennium, the cultural habits of Welsh speakers, particularly with ...
Humphrey Lloyd Humphreys
doaj   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Challenges in Early Years data and their implications on programme evaluations

International Journal of Population Data Science
The Welsh Government funds a wide range of Early Years programmes to both support parents to remain in work and children’s social, emotional and educational development.
Silvia Colonna, Kathryn Helliwell
doaj   +1 more source

Bespoke geometric glazing design for building energy performance analysis [PDF]

FME Transactions, 2019
Geometry is an important architectural design issue in the assessment of a building model's energy performance using Building Performance Simulation tools.
Wardhana Nicholas Mario, Chatzivasileiadi Aikaterini, Jabi Wassim, Aish Robert, Lannon Simon   +4 more
doaj  

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Use of an Esophageal Heat Exchanger to Maintain Core Temperature during Burn Excisions and to Attenuate Pyrexia on the Burns Intensive Care Unit

Case Reports in Anesthesiology, 2016
Introduction. Burns patients are vulnerable to hyperthermia due to sepsis and SIRS and to hypothermia due to heat loss during excision surgery. Both states are associated with increased morbidity and mortality.
David Williams, Gordon Leslie, Dimitrios Kyriazis, Benjamin O’Donovan, Joanne Bowes, John Dingley   +5 more
doaj   +1 more source

Involvement of Gibberellins in the Regulation of Tillering in Welsh Onion ( Allium fistulosum L.)

, 2015
We investigated the effects of applied gibberellin A3 (GA3) and uniconazole P (UCP), a GA biosynthesis inhibitor, on tillering in Welsh onion, also known as Japanese bunching onion ‘Hangzhou’, a cultivar with very high tillering capacity.
H. Yamazaki, N. Shiraiwa, A. Itai, I. Honda   +3 more
semanticscholar   +1 more source

RNA-Seq Reveals Leaf Cuticular Wax-Related Genes in Welsh Onion

PLoS ONE, 2014
The waxy cuticle plays a very important role in plant resistance to various biotic and abiotic stresses and is an important characteristic of Welsh onions.
Qianchun Liu, Changlong Wen, Hong Zhao, Liying Zhang, Jian Wang, Yongqin Wang   +5 more
semanticscholar   +1 more source