Results 81 to 90 of about 2,574,835 (312)

Ageing in Werner syndrome

BioScience Trends, 2012
Oxidative stress markers including pentosidine and homocysteine were examined comparing them with inflammation markers including highly sensitive C-reactive protein (hsCRP) and matrix metalloproteinase-9 (MMP-9) in serum from patients with Werner syndrome (WS) and healthy individuals.
Makoto Goto, Yasuhiro Watanabe, Sachiko Iwaki-Egawa   +2 more
openaire   +3 more sources

DNA repair: Disorders [PDF]

, 2010
No description ...
Bose, Burg, Caldecott, Chu, Digweed, Fernandez-Capetillo, Fousteri, Fousteri, Friedberg, Gudmundsdottir, Hashimoto, Hoeijmakers, Jiricny, Kraemer, Lavin, Lehmann, Lieber, Ma, Masutani, McCulloch, Meindl, Moldovan, Moshous, Nance, Nouspikel, O'Driscoll, O'Driscoll, O'Driscoll, O'Driscoll, Rass, Stefanini, Stewart, Stracker, Taylor, Vaz, Wu, Zlatanou   +36 more
core   +1 more source

An exploration of market mechanisms to the wicked problem of space debris 太空垃圾棘手问题的市场机制探究 Una exploración de los mecanismos del mercado para resolver el complejo problema de los desechos espaciales

Risk, Hazards &Crisis in Public Policy, EarlyView.
Abstract Near‐earth orbits are becoming congested because of a rapid growth in the number of satellites and space debris, which presents a real threat to the sustainable use of space and the safety of the Earth. Despite space scientists and public policymakers having been actively seeking solutions for decades, solving the problem has been put off ...
Anna Ya Ni, Maureen Mayala, Faith Victoria Ni   +2 more
wiley   +1 more source

Homozygosity for the WRN Helicase-Inactivating Variant, R834C, does not confer a Werner syndrome clinical phenotype

Scientific Reports, 2017
Loss-of-function mutations in the WRN helicase gene cause Werner syndrome- a progeroid syndrome with an elevated risk of cancer and other age-associated diseases. Large numbers of single nucleotide polymorphisms have been identified in WRN.
A. Kamath-Loeb, Diego G. Zavala-van Rankin, Jeny Flores-Morales, M. Emond, J. Sidorova, A. Carnevale, Maria del Carmen Cárdenas-Cortés, T. Norwood, R. Monnat, L. Loeb, Gabriela E Mercado-Celis   +10 more
semanticscholar   +1 more source

Síndrome de Werner: Dos nuevos casos Werner´S Syndrome: Two New Cases

Revista Argentina de Dermatología, 2010
Se comunican dos casos del síndrome de Werner, el primero es un hombre con canicie desde la tercera década de la vida y diabetes mellitus diagnosticada el año pasado.
M Palombo, S Monroy, RE Achenbach
doaj  

Nicotinamide Riboside Supplementation Benefits in Patients With Werner Syndrome: A Double‐Blind Randomized Crossover Placebo‐Controlled Trial

Aging Cell, EarlyView.
Nicotinamide riboside improved arterial stiffness (cardio–ankle vascular index), reduced skin ulcer area, and showed a trend toward mitigating heel pad thinning in patients with Werner syndrome, with no serious adverse events. Metabolomic analysis revealed a significant decrease in creatinine, suggesting a potential suppression of renal functional ...
Mayumi Shoji, Hisaya Kato, Masaya Koshizaka, Hiyori Kaneko, Yusuke Baba, Takahiro Ishikawa, Naoya Teramoto, Daisuke Kinoshita, Ayano Yamaguchi, Yukari Maeda, Yosuke Inaba, Yuki Shiko, Yoshihito Ozawa, Vilhelm A. Bohr, Yoshiro Maezawa, Koutaro Yokote   +15 more
wiley   +1 more source

Ccdc11 is a novel centriolar satellite protein essential for ciliogenesis and establishment of left-right asymmetry [PDF]

, 2016
The establishment of left–right (L-R) asymmetry in vertebrates is dependent on the sensory and motile functions of cilia during embryogenesis. Mutations in CCDC11 disrupt L-R asymmetry and cause congenital heart disease in humans, yet the molecular and ...
Betleja, Ewelina, John, Emily, Mahjoub, Moe R, Mitchell, Brian J, Moresco, James J, Silva, Erica, Spear, Philip, Yates, John R, III, Zhang, Siwei   +8 more
core   +2 more sources

Identification of Functional Cellular Markers Related to Human Health, Frailty and Chronological Age

Aging Cell, EarlyView.
Human skin fibroblasts in vitro preserve the memory of age and health. ABSTRACT Aging leads to a decline in physiological reserves, an increase in age‐related diseases, reduced functional ability and a shortened healthspan. While molecular markers of chronological aging exist, their link to general health and intrinsic capacity (IC), a composite ...
Chloé Brodeau, Camille Joly, Anaïs Chekroun, Jean Nakhle, Vincent Blase, Nicolas Espagnolle, Cédric Dray, Armelle Yart, Valérie Planat, Margot Tertrais, Julien Fassy, Sophie Guyonnet, Wan‐Hsuan Lu, Philipe de Souto Barreto, Olivier Teste, Marie Tremblay‐Franco, Kamaryn T. Tanner, Alan A. Cohen, Audrey Carriere, Louis Casteilla, Isabelle Ader, IHU HealthAge/Open Science group   +21 more
wiley   +1 more source

Werner syndrome: a model for sarcopenia due to accelerated aging

Aging, 2017
Werner syndrome (WS) is a rare inheritable progeroid syndrome caused by a mutation in the WRN gene. Although WS has been described as a characteristic appearance of very slender extremities with a stocky trunk, few studies have investigated the loss of ...
Masaya Yamaga, M. Takemoto, Mayumi Shoji, Kenichi Sakamoto, Masashi Yamamoto, T. Ishikawa, M. Koshizaka, Y. Maezawa, Kazuki Kobayashi, K. Yokote   +9 more
semanticscholar   +1 more source

Herlyn Werner Wunderlich Syndrome with Hydrocolpos: A Case Report

Journal of Nepal Medical Association
Herlyn-Werner-Wunderlich Syndrome is a very rare congenital malformation of the urogenital tract involving both the Mullerian and Wolffian ducts characterized by the triad uterine diadelphys, obstructed vagina, and unilateral renal agenesis.
Saurav Sen Oli, Shova Sapkota, Rupa Bajagain, Rachana Saha, Suman Paudel   +4 more
doaj   +1 more source