Results 31 to 40 of about 6,982,453 (289)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Advice to Students Considering Graduate Work in English [PDF]
, 2004 Drawing on specific case histories from over 50 students who applied to graduate programs in English Literature, Composition, and Writing, this document represents my advice to students applying nationwide to do graduate work in the various subfields of ...
West, Michael
core +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Rights, Harms, and Duties: A Response to \u3ci\u3eJustice for Hedgehogs\u3c/i\u3e [PDF]
, 2010 The author responds to the three jurisprudential positions that Ronald Dworkin discusses in his book--albeit briefly--so as to integrate them into his hedgehoggian program. The first is that we should think of rights as political trumps, such that the
West, Robin
core +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
A Holistic Approach to Jesus the Nazarene in Matthew 2:23 [PDF]
, 2018 In Matthew 2:23 Jesus is said to have fulfilled what the prophets spoke when he and his family moved to Nazareth, that he shall be called a Nazarene. Due to the uniqueness of this term and the town of Nazareth being found nowhere in the Old Testament ...
West, Dylan
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Сравнительная политика, 2017 This article examines the widely held presumption that in the light of the recent uptick in tension between Russia and the West, a Russian-Chinese alliance has emerged to challenge the United States and its allies.
Toni Michel
doaj +1 more source
The Authoritarian Impulse in Constitutional Law [PDF]
, 1988 Should there be greater participation by legislators and citizens in constitutional debate, theory, and decision-making? An increasing number of legal theorists from otherwise divergent perspectives have recently argued against what Paul Brest calls the
West, Robin
core +2 more sources