Results 141 to 150 of about 1,852,134 (302)

Geopolitics versus business interests: The case of the Siberian gas-pipeline in the 1980s [PDF]

open access: yes
The discovery of a huge gas deposit in North Siberia in the 1980s changed somewhat western Europe economy, because an abundant and low cost energy source allowed to alleviate the burden of the 'energy crisis' and, above all, paved the way to a large ...
Hubert BONIN (GRES-CMHE)
core  

NIPAL1 Drives a Metabolic‐Epigenetic Feedback Loop to Promote Lactate‐Mediated Immune Evasion in Esophageal Cancer

open access: yesAdvanced Science, EarlyView.
The study identifies a NIPAL1‐driven metabolic‐epigenetic circuit in esophageal squamous cell carcinoma that promotes glycolysis, lactate accumulation, and H3K18 histone lactylation, forming a self‐sustaining loop that suppresses CD8+ T cell immunity.
Ri‐Xin Chen   +15 more
wiley   +1 more source

Options for Transporting Russian Gas to Western Europe: A Game-theoretic Simulation Analysis [PDF]

open access: yes
This paper examines the perspectives of Russian gas exports to Western Europe and the strategic options of the CIS gas transiting countries, namely Ukraine and Belarus.The development of a new transit corridor through Belarus (the Yamal-Europe pipeline),
Andreas Chollet   +3 more
core  

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

open access: yesAdvanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu   +16 more
wiley   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

open access: yesAdvanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li   +5 more
wiley   +1 more source

Welfare Policies in the UNECE Region: Why so Different? [PDF]

open access: yes
This paper provides the text of the Gunnar Myrdal Lecture presented at the U.N. Palais des Nations in 2006. It provides an analysis of why different countries in the western world have chosen different models of the welfare state.
Alberto Alesina
core  

Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1‐Mediated M1 Macrophage Polarization in Sarcoidosis

open access: yesAdvanced Science, EarlyView.
Legumain (LGMN) is upregulated in macrophages during sarcoid‑like granuloma formation. Macrophage‑derived LGMN binds to integrin αvβ3 and suppresses mTORC1/STAT1 signaling to restrain M1 macrophage polarization. Intratracheal delivery of lipid nanoparticles carrying Lgmn plasmid DNA (pDNA) elevates LGMN expression and effectively attenuates pulmonary ...
Mengyuan Liu   +12 more
wiley   +1 more source

DETERMINANTS OF PRIVATE EQUITY FUNDRAISING IN WESTERN EUROPE [PDF]

open access: yes
The aim of this paper is to identify the key factors that lie behind venture capital/private equity fundraising in countries where there is scarce and asymmetric information about final returns.
José Martí Pellón, Marina Balboa
core  

Lipoic Acid‐Intervened Decellularized Stem Cell Spheroid‐Based Injectable Granular Gel for Diabetic Tissue Regeneration

open access: yesAdvanced Science, EarlyView.
ABSTRACT Advancements in tissue engineering have revolutionized therapeutic paradigms for diabetic tissue defects; however, the lack of applicable scaffold containing various bioactive substance aggregates remained a critical bottleneck hindering satisfactory repair effect.
Tao Wang   +8 more
wiley   +1 more source

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