Results 21 to 30 of about 258,169 (218)

The debated question of asymmetrical rhynchonellids (Brachiopoda, Rhynchonellida): examples from the Late Cretaceous of Western Europe

BSGF - Earth Sciences Bulletin, 2020
Many Cretaceous asymmetrical rhynchonellid brachiopods (Brachiopoda, Rhynchonellida) have long been considered as Rhynchonella difformis (Valenciennes in Lamarck, 1819).
Gaspard Danièle, Charbonnier Sylvain
doaj   +1 more source

Effect of DFPP on Ferroptosis in Peripheral Blood CD14+ Monocytes of Hyperlipidemic Patients Involving the ACSL4/LPCAT3/ALOX5 Pathway

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng, Lan Li, Qingmei Yang, Meipeng Wu   +3 more
wiley   +1 more source

A staged clinical development and evidence-generation framework for Group A Streptococcus vaccines

npj Vaccines
Group A Streptococcus (Strep A) causes substantial global morbidity and mortality, yet vaccine development faces scientific, regulatory, and strategic challenges.
Alberto Cagigi, Annette Kraus, T. Anh Wartel, Andrew Steer, Jonathan Carapetis, Alma Fulurija, Jerome H. Kim   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Development of a new method to quantify filler dispersion in bituminous mastics by transmission microscopy and image analysis

Scientific Reports
This study introduces a novel method to analyze how fillers disperse in bituminous binders. A custom-designed laboratory setup enables precise temperature control (140 °C) and mixing speeds (200, 800, 1500 rpm) for small-scale mixtures (5% filler) over 5,
Marouane Ouazri, Walid Maherzi, Didier Lesueur, Lahcen Khouchaf   +3 more
doaj   +1 more source

Changing European retail landscapes: New trends and challenges

Moravian Geographical Reports, 2018
During the second half of the 20thcentury, consumption patterns in the developed market economies have stabilised, while in the transition/EU-accession countries these patterns were accepted with unusual speed and dynamics.
Kunc Josef, Križan František
doaj   +1 more source

Language policy in education and its role in preservation of minority languages in Russia and other countries

Ученые записки Казанского университета: Серия Гуманитарные науки, 2020
The language policy in education and the role of education in the preservation and development of minority languages were discussed. The main approaches and models used for teaching minority languages in Russian and Western European schools were compared.
E.V. Khilkhanova
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source