Results 41 to 50 of about 1,852,134 (302)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

The Representative Potential of Interest Groups: Internal Voice in Post-Communist and Western European Countries

Politics and Governance, 2023
Why do some interest group systems provide group members with more elaborate voice opportunities than other systems? We argue that evaluating membership voice is important for understanding the representative potential of interest group systems.
Joost Berkhout, Jan Beyers, Marcel Hanegraaff   +2 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

COVID-19: Monitoring the propagation of the first waves of the pandemic

4 open, 2020
Introduction: A phenomenological approach is proposed to monitor the propagation of the first waves of the COVID-19 pandemic. Method: A large set of data collected during the first months of 2020 is compiled into a series of semi-logarithmic ...
Knafo William
doaj   +1 more source

The historical regions of Europe: civilizational backgrounds and multiple routes to modernity [PDF]

, 2012
A systematic typology or comparative analysis of European historical regions does not exist and there is relatively little literature on the topic. The argument in this paper is that a six-fold classification is needed to capture the diversity of Europe ...
Delanty, Gerard
core   +2 more sources

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Ancient tin production: Slags from the Iron Age Carvalhelhos hillfort (NW Iberian Peninsula) [PDF]

, 2018
Provenance and production of tin in the Ancient World has since long been a major topic of discussion among archaeologists. In Western Europe, where significant tin ore (cassiterite) deposits are known, only a few remains of ancient tin production, such ...
Figueiredo, Elin, Fonte, João, Lima, Alexandre, Mirão, José, Silva, Rui J.C., Veiga, João Pedro   +5 more
core   +1 more source

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

Why are the railways of Eastern Europe less efficient than those of the West?

Transport Economics and Management
We use a DEA analysis to compare the efficiency of the railways of Western and Eastern Europe and find while most railways of Western Europe are on the efficiency frontier, those of Eastern Europe are typically a long way from it.
Hana Fitzová, Chris Nash
doaj   +1 more source

A tale of two capitalisms: preliminary spatial and historical comparisons of homicide rates in Western Europe and the USA [PDF]

, 2009
This article examines comparative homicide rates in the United States and Western Europe in an era of increasingly globalized neoliberal economics. The main finding of this preliminary analysis is that historical and spatial correlations between distinct
Ames, M., Amin, S., Badiou, A., Barclay, G., Barclay, G., Bauman, Z., BBC News, BBC News, BBC News, Boltanski, L., Bonger, W., Cavadino, M., Craig McLean, Dorling, D., Downes, D., Elias, N., Fletcher, J., Fukuyama, F., Garland, D., Gray, J., Green, P., Greenberg, D.F., Hagan, J., Hagedorn, J.M., Hall, S., Hall, S., Hallsworth, S., Held, D., Hirst, P., Hutton, W., Kearon, T., Lane, R., Lasch, C., Lea, J., Luxemburg, R., Merton, R., Messner, S.F., Naughton, B., Ohmae, K., Ohmae, K., Polanyi, K., Rancière, J., Rawls, J., Reiner, R., Reiner, R., Rorty, R., Ruggiero, V., Slotkin, R., Spierenburg, P., Squires, P., Steve Hall, Tawney, R.H., Taylor, I., Todd, E., Tombs, S., Trachtenberg, A., United Nations, Walmsley, R., Wilson, J.Q., Winlow, S., Woodiwiss, M., Young, J., Young, J., Young, J., Zimring, F.E., Zinn, H., Žižek, S.   +66 more
core   +1 more source