Results 41 to 50 of about 351,727 (307)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

In Search of the Healthy Immigrant Effect in Four West European Countries

Social Inclusion, 2019
The present research examines whether the ‘healthy immigrant effect’ thesis observed in the American context prevails also in the West European context. According to this thesis, immigrants are likely to be healthier than comparable nativeborn.
Dina Maskileyson, Moshe Semyonov, Eldad Davidov   +2 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Political Communication Cultures in Western Europe [Elektronisk resurs] : Technical Report: Sweden [PDF]

, 2008
The objective of the international study Political Communication Cultures in Western Europe is to analyse the attitudes, norms, and values that drive the relationship between political actors and journalists and thereby detect the underlying patterns of ...
Håkansson, Nicklas,
core  

Intercontinental differences in overweight of adopted Koreans in the United States and Europe [PDF]

, 2012
A greater proportion of the United States (US) population is overweight or obese (with BMI over 25 kg/m2) relative to all Western European populations, and it might be expected that migrants to either the US or Western Europe would develop patterns of ...
Ulijaszek, Stanley, Schwekendiek, Daniel
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Organizing interests in Western Europe : pluralism, corporatism, and the transformation of politics / [PDF]

, 1981
Includes bibliographical references and index."Sponsored by the Joint Committee on Western Europe of the Social Science Research Council and the American Council of Learned Societies.
Berger, Suzanne,edt, Joint Committee on Western Europe.   +1 more
core  

COVID-19: Monitoring the propagation of the first waves of the pandemic

4 open, 2020
Introduction: A phenomenological approach is proposed to monitor the propagation of the first waves of the COVID-19 pandemic. Method: A large set of data collected during the first months of 2020 is compiled into a series of semi-logarithmic ...
Knafo William
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The politics of public-private partnerships in western Europe: comparative perspectives [PDF]

, 2016
The Politics of Public-Private Partnerships in Western Europe: Comparative Perspectives The role of the European judiciary has, in recent years, undergone a significant upheaval that has led to a realignment of judicial, legislative and executive powers.
Krumm, Thomas
core   +1 more source