Results 31 to 40 of about 4,039,961 (280)
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Scientific ReportsThis study introduces a novel method to analyze how fillers disperse in bituminous binders. A custom-designed laboratory setup enables precise temperature control (140 °C) and mixing speeds (200, 800, 1500 rpm) for small-scale mixtures (5% filler) over 5,
Marouane Ouazri +3 more
doaj +1 more source
People’s Houses as Answers to the Challenges of Modernity in Europe and Russia
RUDN Journal of Russian History, 2020 The article is devoted to a pioneer comparative study of the appearance and evolution of peoples houses in Western Europe and Russia in the second half of the XIX - early XX century.
Elena V. Alekseeva +1 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
In Search of the Healthy Immigrant Effect in Four West European Countries
Social Inclusion, 2019 The present research examines whether the ‘healthy immigrant effect’ thesis observed in the American context prevails also in the West European context. According to this thesis, immigrants are likely to be healthier than comparable nativeborn.
Dina Maskileyson +2 more
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Western String Chamber Orchestra, November 14, 1996
, 2016 Recorded during a live performance at Dalton Center Recital Hall, Western Michigan University, Kalamazoo, Michigan, November 14, 1996, 8:00 p.m., the 137th concert of the School of Music's 1996-1997 season.Western String Chamber Orchestra, Bruce J ...
Western String Chamber Orchestra
core +2 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
COVID-19: Monitoring the propagation of the first waves of the pandemic
4 open, 2020 Introduction: A phenomenological approach is proposed to monitor the propagation of the first waves of the COVID-19 pandemic. Method: A large set of data collected during the first months of 2020 is compiled into a series of semi-logarithmic ...
Knafo William
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source