Results 31 to 40 of about 1,852,134 (302)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Changing European retail landscapes: New trends and challenges
Moravian Geographical Reports, 2018 During the second half of the 20thcentury, consumption patterns in the developed market economies have stabilised, while in the transition/EU-accession countries these patterns were accepted with unusual speed and dynamics.
Kunc Josef, Križan František
doaj +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Scientific ReportsThis study introduces a novel method to analyze how fillers disperse in bituminous binders. A custom-designed laboratory setup enables precise temperature control (140 °C) and mixing speeds (200, 800, 1500 rpm) for small-scale mixtures (5% filler) over 5,
Marouane Ouazri +3 more
doaj +1 more source
Ученые записки Казанского университета: Серия Гуманитарные науки, 2020 The language policy in education and the role of education in the preservation and development of minority languages were discussed. The main approaches and models used for teaching minority languages in Russian and Western European schools were compared.
E.V. Khilkhanova
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
In Search of the Healthy Immigrant Effect in Four West European Countries
Social Inclusion, 2019 The present research examines whether the ‘healthy immigrant effect’ thesis observed in the American context prevails also in the West European context. According to this thesis, immigrants are likely to be healthier than comparable nativeborn.
Dina Maskileyson +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
People’s Houses as Answers to the Challenges of Modernity in Europe and Russia
RUDN Journal of Russian History, 2020 The article is devoted to a pioneer comparative study of the appearance and evolution of peoples houses in Western Europe and Russia in the second half of the XIX - early XX century.
Elena V. Alekseeva +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source