Results 31 to 40 of about 1,843,358 (306)

Development of a new method to quantify filler dispersion in bituminous mastics by transmission microscopy and image analysis

Scientific Reports
This study introduces a novel method to analyze how fillers disperse in bituminous binders. A custom-designed laboratory setup enables precise temperature control (140 °C) and mixing speeds (200, 800, 1500 rpm) for small-scale mixtures (5% filler) over 5,
Marouane Ouazri, Walid Maherzi, Didier Lesueur, Lahcen Khouchaf   +3 more
doaj   +1 more source

Language policy in education and its role in preservation of minority languages in Russia and other countries

Ученые записки Казанского университета: Серия Гуманитарные науки, 2020
The language policy in education and the role of education in the preservation and development of minority languages were discussed. The main approaches and models used for teaching minority languages in Russian and Western European schools were compared.
E.V. Khilkhanova
doaj   +1 more source

Ancient tin production: Slags from the Iron Age Carvalhelhos hillfort (NW Iberian Peninsula) [PDF]

, 2018
Provenance and production of tin in the Ancient World has since long been a major topic of discussion among archaeologists. In Western Europe, where significant tin ore (cassiterite) deposits are known, only a few remains of ancient tin production, such ...
Figueiredo, Elin, Fonte, João, Lima, Alexandre, Mirão, José, Silva, Rui J.C., Veiga, João Pedro   +5 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

In Search of the Healthy Immigrant Effect in Four West European Countries

Social Inclusion, 2019
The present research examines whether the ‘healthy immigrant effect’ thesis observed in the American context prevails also in the West European context. According to this thesis, immigrants are likely to be healthier than comparable nativeborn.
Dina Maskileyson, Moshe Semyonov, Eldad Davidov   +2 more
doaj   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

People’s Houses as Answers to the Challenges of Modernity in Europe and Russia

RUDN Journal of Russian History, 2020
The article is devoted to a pioneer comparative study of the appearance and evolution of peoples houses in Western Europe and Russia in the second half of the XIX - early XX century.
Elena V. Alekseeva, Elena Y. Kazakova-Apkarimova   +1 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

The historical regions of Europe: civilizational backgrounds and multiple routes to modernity [PDF]

, 2012
A systematic typology or comparative analysis of European historical regions does not exist and there is relatively little literature on the topic. The argument in this paper is that a six-fold classification is needed to capture the diversity of Europe ...
Delanty, Gerard
core   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source