Results 241 to 250 of about 641,848 (268)

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

SARS-CoV-2 membrane protein recruits PP2A to dephosphorylate the nucleocapsid and promote virion production. [PDF]

J Biomed Sci
Wang SH, Chao TL, Hsieh CL, Chen PJ, Chang SY, Yeh SH.   +5 more
europepmc   +1 more source

Viral dsRNA triggers human fetal membrane miR-146a-3p to be packaged into small extracellular vesicles which in turn drives inflammation through activation of Toll-like Receptor 7 and 8. [PDF]

PLoS One
Georges HM, Fischer AC, Casanova P, Abrahams VM.   +3 more
europepmc   +1 more source

Ubiquitin ligase ITCH regulates life cycle of SARS-CoV-2 virus. [PDF]

Elife
Xiang Q, Wouters C, Chang P, Lu YN, Liu M, Wang H, Heine H, Qian S, Yang J, Pekosz A, Zhang Y, Wang J.   +11 more
europepmc   +1 more source

Purified zymogens reveal mechanisms of snake venom metalloproteinase auto-activation. [PDF]

Elife
Hall S, Cardoso IA, Wilkinson MC, Carretero MM, Lingappa S, Rand B, Shen D, Boldrini-França J, Stenner R, Menzies SK, Balchin G, Hus KK, Vincentelli R, Mumford A, Poole A, Casewell NR, Berger I, Schaffitzel C.   +17 more
europepmc   +1 more source

EHMT2 aggravates vascular remodeling via epigenetic inhibition of GADD45G. [PDF]

Exp Mol Med
Wang Z, Zhao J, Luo W, Sun N, Ma X, Zhong F, Wu B, Tang H, Ning K, He J, Wang X, Zhang K, Zhang J, Liu C, Ren J, Zhao Y, Qin Z.   +16 more
europepmc   +1 more source

Global Sentiment Toward Health AI at the Dawn of the ChatGPT Era: Empirical Analysis of Twitter (X) Discourse. [PDF]

J Med Internet Res
Wass LM, Wu Z, Vizoso J, Wu JT, Lin L.
europepmc   +1 more source

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Africa's global media image in a digital world as an exclusive western preserve?

International Communication Gazette, 2022
Chikaire Ezeru
exaly  

Encounters with Western media theory: Asian perspectives

Media, Culture and Society, 2021
Dal Yong Jin
exaly