Results 1 to 10 of about 135,271 (155)

Extracellular vesicles derived from EphB2-overexpressing bone marrow mesenchymal stem cells ameliorate DSS-induced colitis by modulating immune balance

Stem Cell Research & Therapy, 2021
Background The bone marrow mesenchymal stem cell (BMSCs)-derived extracellular vesicles (EVs) open up a new avenue for ulcerative colitis (UC) treatment recently, but they are not selectively enriched in targeted tissues.
Ting Yu, Si Chu, Xingxing Liu, Junyi Li, Qianyun Chen, Meng Xu, Hui Wu, Mingyue Li, Yalan Dong, Feng Zhu, Haifeng Zhou, Desheng Hu, Heng Fan   +12 more
doaj   +1 more source

Therapy of traumatic brain injury by modern agents and traditional Chinese medicine

Chinese Medicine, 2023
Traumatic brain injury (TBI) is the leading cause of disability and death, and the social burden of mortality and morbidity caused by TBI is significant.
Chunzhu Wei, Jingbo Wang, Jintao Yu, Qing Tang, Xinjie Liu, Yanlong Zhang, Dandan Cui, Yanqiong Zhu, Yanli Mei, Yanjun Wang, Wenzhu Wang   +10 more
doaj   +1 more source

Honokiol alleviates LPS-induced acute lung injury by inhibiting NLRP3 inflammasome-mediated pyroptosis via Nrf2 activation in vitro and in vivo

Chinese Medicine, 2021
Background Honokiol (HKL) has been reported to ameliorate lipopolysaccharide (LPS)-induced acute lung injury (ALI). However, its potential mechanism of its protective effects remains unclear.
Yuhan Liu, Jiabin Zhou, Yingying Luo, Jinxiao Li, Luorui Shang, Fangyuan Zhou, Shenglan Yang   +6 more
doaj   +1 more source

The analysis of Modified Qing’ E Formula on the differential expression of exosomal miRNAs in the femoral head bone tissue of mice with steroid-induced ischemic necrosis of femoral head

Frontiers in Endocrinology, 2022
ObjectiveTo investigate the differential expression of exosomal miRNAs in the bone marrow tissue of Modified Qing’ E Formula (MQEF) on steroid-induced ischemic necrosis of the femoral head (INFH) model.MethodsSteroid hormones were used to establish the ...
Wei Zhu, Wei Zhu, Faxue Zhang, Faxue Zhang, Junjie Lu, Chen Ma, Lin Shen, Desheng Hu, Xiaojuan Xu, Bo Shuai   +9 more
doaj   +1 more source

Unia Europejska wobec Bałkanów Zachodnich w kontekście kryzysu migracyjnego w latach 2015‑2019

Politeja, 2020
European Union towards Western Balkans in the Context of Migration Crisis 2015‑2019 The aim of the article is to analyse the actions taken by the European Union towards the Western Balkans in the context of the migration crisis. The study assumes that
Wawrzyniec Banach
doaj   +1 more source

The Western Balkans – an area of geopolitical competition [PDF]

Romanian Journal of Society and Politics, 2022
The Covid-19 pandemic highlighted the strong interdependencies and vulnerability of the EU, especially when in competition with other external actors. On the other hand, the slow pace of reforms and the increasingly uncertain domestic context, coupled ...
Oana Cristea
doaj  

Long‐term effects of obesity on COVID‐19 patients discharged from hospital

Immunity, Inflammation and Disease, 2021
Introduction Obesity has been reported as a risk factor for COVID‐19 prognosis. However, the long‐term effects of obesity on patients discharged from the hospital are unclear, and the present study aims to address this issue.
Luorui Shang, Li Wang, Fangyuan Zhou, Jinxiao Li, Yuhan Liu, Shenglan Yang   +5 more
doaj   +1 more source

Current comprehensive understanding of denosumab (the RANKL neutralizing antibody) in the treatment of bone metastasis of malignant tumors, including pharmacological mechanism and clinical trials

Frontiers in Oncology, 2023
Denosumab, a fully humanized monoclonal neutralizing antibody, inhibits activation of the RANK/RANKL/OPG signaling pathway through competitive binding with RANKL, thereby inhibiting osteoclast-mediated bone resorption.
Junjie Lu, Desheng Hu, Yan Zhang, Chen Ma, Lin Shen, Bo Shuai   +5 more
doaj   +1 more source

Integrated network pharmacology and experimental verification to investigate the mechanisms of YYFZBJS against colorectal cancer via CDK1/PI3K/Akt signaling

Frontiers in Oncology, 2022
BackgroundColorectal cancer (CRC) is a common digestive tract malignancy with rising incidence and morbidity worldwide during recent years. Yi-Yi-Fu-Zi-Bai-Jiang-San (YYFZBJS), a traditional Chinese medicine formula, has showed positive effects against ...
Jinxiao Li, Fangyuan Zhou, Luorui Shang, Na Liu, Yuhan Liu, Mengqi Zhang, Shuhan Wang, Shenglan Yang, Shenglan Yang   +8 more
doaj   +1 more source

Background and formation of cooperation between European Union member states in the field of defense

Теорія і практика правознавства, 2019
The historical way of development of integration processes in the defence sphere, starting with the end of World War II up to nowadays, appeared to be rather complicated.
Юлія Володимирівна Петренко
doaj   +1 more source