Results 11 to 20 of about 135,370 (254)

Multifaceted functions of STING in human health and disease: from molecular mechanism to targeted strategy

Signal Transduction and Targeted Therapy, 2022
Since the discovery of Stimulator of Interferon Genes (STING) as an important pivot for cytosolic DNA sensation and interferon (IFN) induction, intensive efforts have been endeavored to clarify the molecular mechanism of its activation, its physiological
Zili Zhang, Haifeng Zhou, Xiaohu Ouyang, Yalan Dong, Alexey Sarapultsev, Shanshan Luo, Desheng Hu   +6 more
doaj   +1 more source

THE BALKANS – BETWEEN EUROPE AND RUSSIA [PDF]

Romanian Journal of Historical Studies, 2021
The article makes an analysis on evolutions in the Balkans, the impact of the crisis in Ukraine and Russia’s actions for the security, stability and development of the Balkan region; escalating tensions and competition among Russia and West to gain ...
Paraschiva Bădescu
doaj  

Oridonin promotes endoplasmic reticulum stress via TP53-repressed TCF4 transactivation in colorectal cancer

Journal of Experimental & Clinical Cancer Research, 2023
Background The incidence of colorectal cancer and cancer death rate are increasing every year, and the affected population is becoming younger. Traditional Chinese medicine therapy has a unique effect in prolonging survival time and improving the ...
Fangyuan Zhou, Haiyang Gao, Luorui Shang, Jinxiao Li, Mengqi Zhang, Shuhan Wang, Runze Li, Lin Ye, Shenglan Yang   +8 more
doaj   +1 more source

GAPDH Is a Novel Ferroptosis-Related Marker and Correlates with Immune Microenvironment in Lung Adenocarcinoma

Metabolites, 2023
Lung adenocarcinoma (LUAD) is a prevalent form of lung cancer with high morbidity and fatality rates. Ferroptosis is a type of programmed cell death that is iron-dependent. Recent findings have suggested that ferroptosis inducers have promising prospects
Xiaohu Ouyang, Rui Zhu, Lan Lin, Xunxun Wang, Qigang Zhuang, Desheng Hu   +5 more
doaj   +1 more source

Beneficial Effects of Celastrol on Immune Balance by Modulating Gut Microbiota in Experimental Ulcerative Colitis Mice

Genomics, Proteomics & Bioinformatics, 2022
Ulcerative colitis (UC) is a chronic inflammatory bowel disease caused by many factors including colonic inflammation and microbiota dysbiosis. Previous studies have indicated that celastrol (CSR) has strong anti-inflammatory and immune-inhibitory ...
Mingyue Li, Weina Guo, Yalan Dong, Wenzhu Wang, Chunxia Tian, Zili Zhang, Ting Yu, Haifeng Zhou, Yang Gui, Kaming Xue, Junyi Li, Feng Jiang, Alexey Sarapultsev, Huafang Wang, Ge Zhang, Shanshan Luo, Heng Fan, Desheng Hu   +17 more
doaj   +1 more source

Pyroptosis, inflammasome, and gasdermins in tumor immunity

Innate Immunity, 2023
The gasdermins (GSDM), a family of pore-forming proteins, consist of gasdermin A (GSDMA), gasdermin B (GSDMB), gasdermin C (GSDMC), gasdermin D (GSDMD), gasdermin E (GSDME) and DFNB59 (Pejvakin (PJVK)) in humans.
Xiaohu Ouyang, Junfen Zhou, Lan Lin, Zili Zhang, Shanshan Luo, Desheng Hu   +5 more
doaj   +1 more source

HDAC3 deteriorates colorectal cancer progression via microRNA-296-3p/TGIF1/TGFβ axis

Journal of Experimental & Clinical Cancer Research, 2020
Background The mechanism of histone deacetylase 3 (HDAC3) in colorectal cancer (CRC) has already been discussed. However, the feedback loop of HDAC3/microRNA (miR)-296-3p and transforming growth factor β-induced factor 1 (TGIF1) in CRC has not been ...
Jinxiao Li, Man Hu, Na Liu, Huarong Li, Zhaomin Yu, Qian Yan, Minfeng Zhou, Yayuan Wang, Yanjuan Song, Guangtao Pan, Fengxia Liang, Rui Chen   +11 more
doaj   +1 more source

Modified Qing’ e Pills exerts anti-osteoporosis effects and prevents bone loss by enhancing type H blood vessel formation

Frontiers in Endocrinology, 2022
ObjectiveTo explore whether the modified Qing’ e Pills (MQEP) exerts anti-osteoporotic effects and prevents bone loss by enhancing angiogenesis.MethodsNetwork pharmacology was used to assess whether MQEP has a pro-angiogenic capacity and to predict its ...
Junjie Lu, Desheng Hu, Chen Ma, Xiaojuan Xu, Lin Shen, Jianhui Rong, Jia Zhao, Bo Shuai   +7 more
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Quercetin ameliorates ulcerative colitis by restoring the balance of M2/M1 and repairing the intestinal barrier via downregulating cGAS‒STING pathway

Frontiers in Pharmacology
Macrophage polarization is closely associated with the pathogenesis of ulcerative colitis (UC). Quercetin, a flavonoid, has shown promise as a treatment for inflammatory diseases, but its specific mechanism of action remains unclear.
Fei Gao, Feng Zhu, Bo Shuai, Meng Wu, Chunzhu Wei, Yuyi Yuan, Yang Gui, Yushi Tian, Heng Fan, Hui Wu   +9 more
doaj   +1 more source

Health Literacy, Self‐Efficacy and Knowledge of Sickle Cell Disease Among Caregivers

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a hereditary blood disorder in which abnormal haemoglobin leads to severe anaemia, painful crises and organ failure. Caregivers’ health literacy (HL) – their ability to assess, understand and apply information, and interact with healthcare professionals – is crucial for managing children with SCD, yet ...
Melanie Bruinooge, Maite E. Houwing, Rowena L. Grohssteiner, Ferdows Atiq, Sonja A. M. C. Teuben, Mirjam P. Fransen, Marjon H. Cnossen   +6 more
wiley   +1 more source