Results 191 to 200 of about 135,370 (254)

Nanozyme‐Reinforced miR‐197‐3p Delivery Resets Metabolic and Senescence Pathways to Rejuvenate Osteoarthritic Cartilage

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a progressive and disabling joint disease driven by oxidative stress, chondrocyte senescence and extracellular matrix (ECM) degradation, yet lacks effective disease‐modifying treatments. In this study, we identified miR‐197‐3p as a previously unrecognized, cartilage‐protective miRNA significantly downregulated in both ...
Xuejie Cai, Zehui Lv, Chen Zhang, Xingdong Yang, Ruoying Wang, Yixin Bian, Jiawei Xu, Han Wang, Yingjie Wang, Long Bai, Jiacan Su, Xisheng Weng   +11 more
wiley   +1 more source

Response to the Union's statement on ongoing conflicts and impact on health services. [PDF]

IJTLD Open
Ahmad Khan F, Menzies R, Ashesh A, Bijker E, Brode S, Carter EJ, Casas EC, Campbell J, Denkinger C, Deborggraeve S, Evlampidou I, Furin J, Farhat M, Farouk MMO, Gafar F, Günther G, Guglielmetti L, Isaakidis P, Jouberton F, Khambati N, Khan PY, Khan U, Long R, Law S, Matteelli A, Malden D, Motta I, Murray M, Masini T, Rich M, Ruslami R, Sepulcri C, Sunyoto T, Tunesi S, Wong EB, Zaffagnini A.   +35 more
europepmc   +1 more source

RHINO: An Integrative Multi‐Omics Framework Linking Circadian Physiology to Precision Medicine

Advanced Science, EarlyView.
RHINO (RHythmic Interacting Network for multi‐Omics) is an integrative framework that maps circadian regulation across diverse genetic and disease contexts and prioritizes druggable circadian targets. Released as an AI‐powered interactive web portal, RHINO unifies genetic, regulatory, disease, and drug–target information, enabling context‐specific ...
Ying Chen, Chengxuan Chen, Dishu Zhou, Panpan Liu, Roberto E. López‐Valiente, Yuan Liu, Cam Mong La, Isabella Beraldo Xavier, Sean M. Hartig, Pradip Saha, Zheng Sun, Leng Han, Dongyin Guan   +12 more
wiley   +1 more source

Myosteatosis mediates the link between specific dietary components and colorectal carcinogenesis: from PPLSS multi-center study. [PDF]

Asia Pac J Clin Nutr
Li CW, Hsieh Y, Li C, Zhang Y, Jiang LJ, Yu SL, Dong LC, Tan ZQ, Zhang J, Xu J, Kang Y.   +10 more
europepmc   +1 more source

A Pancreatitis‐Inspired Trypsinogen Nanoplatform Reprograms Tumor‐Associated Macrophages via NF‐κB for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
Trypsinogen‐loaded nanoparticles reprogram TAMs via NF‐κB/NLRP3, driving M2→M1 conversion and potent phagocytosis to unleash antitumor immunity. ABSTRACT Although reprogramming tumor‐associated macrophages (TAMs) represents a promising therapeutic strategy, approaches that are both precise and safe remain scarce.
Lei Cao, Yu He, Wenhao Li, Bo Gong, Han Lin, Jianlin Shi, Yuan Yong, Wencheng Wu   +7 more
wiley   +1 more source

A comparative benchmark of DeepSeek-R1 on the USMLE: surpassing human and AI performance averages. [PDF]

Clinics (Sao Paulo)
Zhou Y, Wang W, Zhao X, Hu K.
europepmc   +1 more source

Ponatinib confers adult human cardiomyocyte toxicity via inhibition of AKT signaling. [PDF]

Physiol Rep
Guo L, Rao R, Liu H, Zhou B.
europepmc   +1 more source

CXCR4 antagonistic lipid nanoparticles loading siRNA combat refractory AML through AML1-ETO depletion and homoharringtonine sensitization. [PDF]

Mater Today Bio
Peng X, Gu R, Wang T, Jiang C, Xing H, Meng J, Wen T, Wang J, Liu J, Xu H.   +9 more
europepmc   +1 more source

Socioeconomic inequalities in life expectancy within and between native-born and foreign-born populations: a comparative study of 10 European countries. [PDF]

Int J Epidemiol
Jang SY, van Lenthe FJ, Myrskylä M, Oksuzyan A, Loi S, Bopp M, Brønnum-Hansen H, Deboosere P, Kalėdienė R, Leinsalu M, Martikainen P, Östergren OM, Psihoda S, Regidor E, Zengarini N, Nusselder WJ.   +15 more
europepmc   +1 more source

Correction: Antisense oligonucleotide targeting TARDBP-EGFR splicing axis inhibits progression of oral squamous cell carcinoma through ABCA1-regulated cholesterol efflux. [PDF]

Int J Oral Sci
Ni N, Wang M, Yuan Z, Zhang L, Cai J, Du Q, Li P, Gao C, Zhang H, Li Y, Yuan H.   +10 more
europepmc   +1 more source