Results 51 to 60 of about 4,564,068 (293)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

open access: yesFEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose   +9 more
wiley   +1 more source

Effect of Structure and Surface Roughness on Wetting Angle of a Hypoeutectic Cast Iron

open access: yesJournal of Advanced Materials in Engineering, 2016
Preliminary results of a research on the effects of microstructure and surface roughness of a hypoeutectic cast iron on its wetting angle are presented in this article.
S. Riahi, B. Niroumand
doaj   +2 more sources

Protocol for quantifying miRNA trafficking across the endosomal membrane

open access: yesFEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh   +2 more
wiley   +1 more source

Theoretical analysis of tracer method for the measurement of wetting efficiency [PDF]

open access: yes, 2007
This work investigates the tracer technique for the measurement of catalyst wetting efficiency, f, in trickle-bed reactor. The model of Ramachandran et al.
Baussaron, Loïc   +7 more
core   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

open access: yesFEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan   +2 more
wiley   +1 more source

Study on the Factors Influencing on Wetting Performance of Blasting Dust in a Limestone Mine

open access: yesGeofluids, 2022
In order to find out the factors influencing on wetting performance of blasting dust in open-pit limestone mines, the blasting dusts in a limestone mine in Tongling, Anhui Province, were studied. The samples of hydrophobic dust (MD) and hydrophilic dust (
Jinrui Nie   +3 more
doaj   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

open access: yesFEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen   +8 more
wiley   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit   +11 more
wiley   +1 more source

Effect of partial wetting on liquid/solid mass transfer in trickle bed reactors [PDF]

open access: yes, 2007
The wetting efficiency of liquid trickle flow over a fixed bed reactor has been measured for a wide range of parameters including operating conditions, bed structure and physico-chemistry of liquid/solid phases.
Baussaron, Loïc   +4 more
core   +1 more source

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