Results 281 to 290 of about 47,201 (334)

Multi‐Omics and Machine Learning‐Uncovered FLT1‐Mediated Epithelial‐Endothelial Crosstalk in Cellular Senescence Driving Clear Cell Renal Cell Carcinoma Malignancy

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
This study integrates multi‐omics data and machine learning to reveal FLT1 as a central mediator of epithelial‐endothelial crosstalk in clear cell renal cell carcinoma (ccRCC). We demonstrate that FLT1‐associated signaling promotes a senescence‐enriched tumor microenvironment, driving malignant progression. Spatial and single‐cell analyses confirm FLT1
Mouyuan Sun, Huchao Mao, Yaxian Luo, Mei Yang, Zhixu He, Shuangyang Li, Zhichao Liu, Lianjie Peng, Quanjie Zhang, Jingyu Zhang, Yan Zhang   +10 more
wiley   +1 more source

Exploratory identification of COL1A1 as a potential gene linking endocrine-disrupting chemicals and lung adenocarcinoma: a bioinformatics and machine learning analysis. [PDF]

BMC Pharmacol Toxicol
She T, Sun F, Xie Z, Cao Y, Xu H.
europepmc   +1 more source

Identificationof CYP2B6 as a Novel Biomarker of HRDin Colon Adenocarcinoma through WGCNA and Machine Learning

Xuemei Gao (694335), Jiahu Yao (19188344), Qizhen Hu (19273111), Changjun Yu (7516), Yang Yang (45629)   +4 more
openalex   +1 more source

Identification and Screening of Lactate‐Related Genes as Molecular Markers for Early Diagnosis of Steroid‐Induced Osteonecrosis of the Femoral Head

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Identification and validation of lactate‐related genes biomarkers for steroid‐induced osteonecrosis of the femoral head through integrated bioinformatics analysis, machine learning, and experimental verification. ABSTRACT Steroid‐induced osteonecrosis of the femoral head (SONFH) is a major cause of disability among young and middle‐aged adults. However,
Zehua Wang, Shuhang Dong, Kaige Xu, Xinyu Tang, Sijia Guo, Yaping Jiang, Yingze Zhang, Tao Li   +7 more
wiley   +1 more source

Identification of key genes modules linking brain aging signatures and COVID-19-associated cognitive impairment. [PDF]

Virus Res
Xie C, Zhao Y, Wang B, He T, Chen J, Wu X.   +5 more
europepmc   +1 more source

Characterization of NLRP3 Inflammasome-Associated Hub Genes in the Progression of Diabetic Nephropathy. [PDF]

Immun Inflamm Dis
Zhao S, Li Y, Li W, Dong L, Lian R, Luo Q, Lian X, Li J, He F.   +8 more
europepmc   +1 more source

FOXC1‐ATP7A Axis Activates PI3K/AKT Signaling to Suppress Cuproptosis and Drive Fibroblast Pathogenesis in Rheumatoid Arthritis

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
This graphical abstract illustrates the regulatory mechanism of the FOXC1‐ATP7A axis in Rheumatoid Arthritis (RA). Bioinformatics analysis identifies FOXC1 as a hub transcription factor that is significantly upregulated in RA synovial tissues and fibroblast‐like synoviocytes (FLSs).
Daomin Lu, Fang Tang, Zong Jiang, Wukai Ma, Changming Chen, Lei Hou, Qianwei Lu, Xueming Yao, Danyang Li, Weiya Lan   +9 more
wiley   +1 more source

Identification and verification of key genes related to oxidative stress in type 2 diabetes and screening of candidate drugs from Traditional Chinese Medicine. [PDF]

J Tradit Chin Med
Jingnan HU, Man L, Zhongwen XI, Jing S, Yining W, Tao HE.   +5 more
europepmc   +1 more source

Stage-Associated Cellular and Molecular Signatures in Diabetic Retinopathy Identified Through Integrated Bulk and Single-Cell Transcriptomic Analysis. [PDF]

Int J Mol Sci
Li Y, Liu L, Zhang Y, Ouyang L, Chen X, Huang J, Ke M.   +6 more
europepmc   +1 more source

Hyperlipidemia-associated specific modules and hub genes revealed by integrative methods of WGCNA and MetaDE. [PDF]

Front Genet
Zhao Z, Cao Y, Gu A, Yao H.
europepmc   +1 more source