Results 331 to 340 of about 57,794 (383)

DNA Methylation Signatures of Cellular Senescence Are Not Reversed by Senolytic Treatment

Aging Cell, Volume 25, Issue 3, March 2026.
We found very little overlap between CpGs that were correlated with in vitro senescence, chronological age, and mortality. While we were able to train epigenetic clocks with CpGs that accelerated with cellular senescence, these clocks did not decelerate with Senolytic treatment. ABSTRACT Epigenetic clocks are commonly used aging biomarkers based on DNA
Jessica Kasamoto, John González, Yaroslav Markov, Raghav Sehgal, Edwin Lee, Varun B. Dwaraka, Ryan Smith, Albert T. Higgins‐Chen   +7 more
wiley   +1 more source

Integrated bioinformatics and machine learning to explore the common mechanisms and potential biomarkers between periodontitis and preterm birth. [PDF]

Front Cell Dev Biol
Mei F, Liu Y, Xu W, Liu R, Wang X, Li T, Chen Y, Wu T, Zhang W.   +8 more
europepmc   +1 more source

Mechanism of ITGB2 in Osteoclast Differentiation in Osteoarthritis

Cell Proliferation, Volume 59, Issue 3, March 2026.
In osteoclast precursors, higher ITGB1 than ITGB2 expression increases ITGA2‐ITGB1 integrin. In OA, extracellular signals upregulate ITGB2 and downregulate ITGB1, enhancing ITGA2‐ITGB2 integrin. This activates Rac1 to Rac‐GTP, driving osteoclast differentiation. Hyperactive subchondral osteoclasts accelerate OA progression.
Yang Yang, Rui Sun, Zhibin Lan, Qi Ma, Gang Wu, Di Xue, Zhirong Chen, Yajing Su, Ye Ma, Xiaolei Chen, Jiangbo Yan, Long Ma, Xiaoxin He, Kuanmin Tian, Xiaoyi Ma, Xue Lin, Qunhua Jin   +16 more
wiley   +1 more source

Integrative Multi-Omics and Machine Learning Identify ID1 as a Candidate Gene Associated with Abdominal Aortic Aneurysm. [PDF]

Curr Issues Mol Biol
Guo F, Keese M, Zhao Y, Fu Q.
europepmc   +1 more source

Beyond nocardioform: Transcriptionally active microbes and host responses in equine mucoid placentitis

Equine Veterinary Journal, Volume 58, Issue 2, Page 601-618, March 2026.
Abstract Background Nocardioform placentitis (NP) is an understudied form of equine placentitis historically attributed to nocardioform bacteria, yet it remains uncertain whether these organisms are the sole pathogens involved. Objectives To elucidate the pathophysiology of NP and the host–pathogen interaction. Study Design In vivo clinical multi‐omics
Machteld van Heule, Margo Verstraete, Jamie Kaj Norris, Kinga Barbara Graniczkowsa, Kirsten E. Scoggin, Hossam El‐Sheikh Ali, Barry A. Ball, Ward De Spiegelaere, Peter Daels, Bart C. Weimer, Pouya Dini   +10 more
wiley   +1 more source

Multi-omics analysis of key lipid metabolism-related genes involved in the anti-hepatocellular carcinoma effect of dihydroartemisinin. [PDF]

Discov Oncol
Guo J, Li L, Chen Y, Gao J, Xie Y, Li Q, Zhang Z.   +6 more
europepmc   +1 more source

Jianpi Jiedu Xiaozheng Fang Regulates Hepatocellular Carcinoma Proliferation and Metastasis Based on Network Pharmacology

Journal of Cellular and Molecular Medicine, Volume 30, Issue 5, March 2026.
ABSTRACT Hepatocellular carcinoma (HCC) is a primary malignant tumour that impacts patients' quality of life. Currently, clinical experience from The First Affiliated Hospital of Guangzhou University of Chinese Medicine suggests that Jianpi Jiedu Xiaozheng Fang (JPJDXZF) demonstrates promising efficacy in the treatment of HCC.
Bin Li, Han‐Qian Shi, Rui Luo, Zi‐Qi Zhang, Xiao‐Chen Dong, Xiao‐Hua Li, Shi‐Qin Ye, Chong Zhong   +7 more
wiley   +1 more source

Characterisation of the gut-lung axis microbiome in clinically stable patients with chronic obstructive pulmonary disease. [PDF]

EBioMedicine
Viglino J, Perea L, Garcia-Nuñez M, Rodrigo-Troyano A, Torrego A, Domínguez-Alvarez M, Villar J, Carrizosa X, Quero S, Gabaldon T, Willis JR, Saus E, Gea J, Santos S, Camps P, Agustí A, Monso E, Sibila O, Faner R.   +18 more
europepmc   +1 more source

oxPAPC‐Mediated lncRNA CYP1B1‐AS1 From Dendritic Cells Accelerates Atherosclerosis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 5, March 2026.
ABSTRACT Oxidised 1‐palmitoyl‐2‐arachidonoyl‐sn‐glycero‐3‐phosphorylcholine (oxPAPC), dendritic cells (DCs), and long non‐coding RNAs (lncRNAs) play crucial roles in atherosclerosis (AS). This study aimed to determine whether oxPAPC‐induced DC‐derived lncRNAs contribute to AS and to elucidate the underlying regulatory mechanisms.
Yuheng Cheng, Lang Ni, Changhao Ke, Yuanjie He, Youyang Huang, Shiwan Lu, Yongchao Zhao, Junbo Ge, Bei Shi, Zhenglong Wang   +9 more
wiley   +1 more source

Transcriptomic analysis identifies hub genes involved in age-dependent abdominal fat development in chickens. [PDF]

Poult Sci
Wei W, Huang N, Chen Z, Jiao J, Zhang C, Wang H, Li C, Guo X, Jiang R.   +8 more
europepmc   +1 more source