Results 241 to 250 of about 90,363 (315)

Integrated epidemiologic investigation and genomic confirmation of a Klebsiella pneumoniae neonatal sepsis outbreak in Botswana. [PDF]

PLOS Glob Public Health
Strysko J, Hu W, Mochankana K, John-Thubuka J, Zankere T, Gopolang B, Theiller E, Jones SM, Tembo CV, Ntereke TD, Gatonye T, Lechiile K, Keatholetswe T, Bianco C, Coffin SE, McGann C, Bittinger K, Lautenbach E, Mannathoko N, Mokomane M, Mosepele M, Richard-Greenblatt M, Nakstad B, Goldfarb DM, Planet PJ, Moustafa AM.   +25 more
europepmc   +1 more source

Understanding and addressing resistance to IMiDs immunomodulatory compounds in multiple myeloma

The FEBS Journal, EarlyView.
IMiDs are pivotal in the treatment of multiple myeloma. Mechanisms of resistance comprise cell intrinsic and extrinsic pathways, involving tumour microenvironment, immune cell dysfunction, CRBN‐dependent and independent genetic drivers and epigenetic changes.
Maria‐Cynthia Fuentes‐Lacouture, Devi Nandana, Karthik Ramasamy, Anjan Thakurta   +3 more
wiley   +1 more source

Real-world clinical utility of tumor whole-genome sequencing in solid cancers. [PDF]

Nat Med
van Putten J, Snaebjornsson P, Bosch LJW, Koster R, Roepman P, Usset J, Boelens MC, van Wezel T, Rosenberg EH, Marchetti S, Vollebergh M, Lambregts DMJ, van der Kolk LE, Cuppen E, Nienhuis HH, Monkhorst K.   +15 more
europepmc   +1 more source

Paediatric‐onset autoimmune cytopenia: How can we reduce the long‐term mortality?

British Journal of Haematology, EarlyView.
Nathalie Aladjidi, Thierry Leblanc, Helder Fernandes, Capucine Picard, Jacinta Bustamante, Frédéric Rieux‐Laucat, Mathieu Fusaro, Maud Tusseau, Charlotte Durand‐Teyssier, Emma Cohendy, Jérôme Granel, Stéphane Ducassou, Agathe Escudier, Despina Moshous, Marc Michel, Bertrand Godeau, Sébastien Héritier, Mony Fahd, Brigitte Bader‐Meunier, Alain Fischer, Guy Leverger, All collaborators from the French Paediatric Haemato‐Immunologic CEREVANCE Network   +21 more
wiley   +1 more source

Gene Editing for Haemophilia—The Next Frontier

Haemophilia, EarlyView.
ABSTRACT The recently approved haemophilia A and B gene therapies via adeno‐associated virus (AAV) showed a promising therapeutic response after a single injection, but there are still limitations, including the potential loss of transgene expression and restriction in adults.
Mirko Pinotti, Gregory A. Newby, Sundar Selvaraj, Steven W. Pipe   +3 more
wiley   +1 more source

Whole genome sequencing for Mycobacterium tuberculosis in public health responses: a review of current practice and enablers in select low-incidence jurisdictions. [PDF]

BMC Public Health
Denholm JT, de Vries G, Anthony R, Robinson E, Backx M, Laurenson IF, Seagar AL, Trieu L, Modestil H, Meissner JS, Ng DHL, Tay JY, Marais BJ, Sintchenko V, Lee R, Donnan EJ.   +15 more
europepmc   +1 more source

Deep intronic ANK1 variants causing pseudo‐exon inclusion in hereditary spherocytosis: Whole‐genome sequencing and functional assessment

British Journal of Haematology, EarlyView.
Victor Marin, Alexandre Janin, Céline Renoux, Yoann Huguenin, AURAGEN consortium, Stéphanie Dulucq, Louis Lebreton, Philippe Joly, Julian Boutin   +8 more
wiley   +1 more source

Performing Large‐Scale Genetic Analysis in the Bleeding Disorders Community

Haemophilia, EarlyView.
ABSTRACT Inherited bleeding disorders encompass a diverse group of conditions caused by genetic defects affecting coagulation factors, fibrinogen, von Willebrand factor, or platelet function. Despite major advances in quantitative and functional laboratory assays, a substantial diagnostic gap remains, particularly in patients with mild or atypical ...
Anna R. Blankstein, Sterre P. E. Willems, Saskia E. M. Schols, Rosanna Asselta, Gillian Lowe, Neil V. Morgan, Paula D. James   +6 more
wiley   +1 more source

Can Artificial Intelligence Be Utilised to Develop Point‐of‐Care Endodontic Microbiological Technologies?

International Endodontic Journal, EarlyView.
ABSTRACT Background Primary or persistent endodontic disease is caused by microbial biofilms that irritate the pulp and periapical tissues. Extensive microbiological analyses of these biofilms and their constituent pathogens have revealed their diversity and complexity.
Ashraf F. Fouad
wiley   +1 more source

Interregional outbreak of <i>Salmonella Typhimurium</i> linked to fresh cheese: A case-case study guided by whole-genome sequencing (WGS), Portugal, March-June 2024. [PDF]

Epidemiol Infect
von Schreeb S, Silveira L, Pista Â, Gomes JP, Oleastro M, Raposo SG, Lutsiv V, Rachadell J, Pinto H, Correia Rico P, Pestana L, Pessoa VL, Carlos Silva A, Dinis A, Almeida MH, Danis K, Vasconcelos P, Pinto Leite P, Ricoca Peixoto V.   +18 more
europepmc   +1 more source