Results 21 to 30 of about 65,945 (217)

The influence of an innovative antibacterial drug of the thiadiazinone class on the virulence factors of bacteria of the phylum Pseudomonadota, which chronically infect patients with cystic fibrosis

Журнал микробиологии, эпидемиологии и иммунобиологии
Introduction. Infections of the lower respiratory tract by bacteria of the Pseudomonadota phylum: Pseudomonas aeruginosa, Burkholderia spp., Achromobacter spp. are critical to the quality and life expectancy of patients with cystic fibrosis (CF).
Olga L. Voronina, Ekaterina A. Koroleva, Marina S. Kunda, Natalia N. Ryzhova, Ekaterina I. Aksenova, Lidia N. Kapotina, Stanislava A. Nelubina, Anna V. Lazareva, Nailya A. Zigangirova   +8 more
doaj   +1 more source

Whole Genome Sequencing for Tracing Geographical Origin of Imported Cases of Human Brucellosis in Sweden

Microorganisms, 2019
Human infections with Brucella melitensis are occasionally reported in Sweden, despite the fact that the national flocks of sheep and goats are officially free from brucellosis. The aim of our study was to analyze 103 isolates of B.
Lorena Sacchini, Tara Wahab, Elisabetta Di Giannatale, Katiuscia Zilli, Anna Abass, Giuliano Garofolo, Anna Janowicz   +6 more
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Scalable, high quality, whole genome sequencing from archived, newborn, dried blood spots

npj Genomic Medicine, 2023
Universal newborn screening (NBS) is a highly successful public health intervention. Archived dried bloodspots (DBS) collected for NBS represent a rich resource for population genomic studies.
Yan Ding, Mallory Owen, Jennie Le, Sergey Batalov, Kevin Chau, Yong Hyun Kwon, Lucita Van Der Kraan, Zaira Bezares-Orin, Zhanyang Zhu, Narayanan Veeraraghavan, Shareef Nahas, Matthew Bainbridge, Joe Gleeson, Rebecca J. Baer, Gretchen Bandoli, Christina Chambers, Stephen F. Kingsmore   +16 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Accuracy benchmark of the GeneMind GenoLab M sequencing platform for WGS and WES analysis [PDF]

, 2022
Chaoyang Li, Xue Fan, Xin Guo, Yongfeng Liu, Miao Wang, Xiao Chao Zhao, Ping Wu, Qin Yan, Lei Sun   +8 more
openalex   +3 more sources

Low-level BTZ-043 resistance in Mycobacterium tuberculosis and cross-resistance to bedaquiline and clofazimine

IJTLD Open
BACKGROUND: Multidrug- and extensively drug-resistant strains of Mycobacterium tuberculosis complex (MTBC) remain a significant global health challenge.
A. Ghodousi, I. Iannucci, F. Saluzzo, J. Dreisbach, S. Mirold-Mei, M. Hoelscher, D.M. Cirillo   +6 more
doaj   +1 more source

Analysis of Drug-Resistance Characteristics and Genetic Diversity of Multidrug-Resistant Tuberculosis Based on Whole-Genome Sequencing on the Hainan Island, China

Infection and Drug Resistance, 2023
Jieying Wang,* Chunchun Yu,* Yuni Xu,* Zhuolin Chen, Wenhua Qiu, Shaowen Chen, Hua Pei, Yeteng Zhong Department of Clinical Laboratory, The Second Affiliated Hospital of Hainan Medical University, Haikou, 570216, People’s Republic of China ...
Wang J, Yu C, Xu Y, Chen Z, Qiu W, Chen S, Pei H, Zhong Y   +7 more
doaj  

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Budućnost cjelogenomskog sekvenciranja u pedijatriji

Liječnički vjesnik, 2023
Sekvenciranje cijeloga genoma (eng. Whole genome sequencing – WGS) postaje sve zastupljeniji genetički dijagnostički test u svakodnevnoj kliničkoj praksi. Inicijativa za medicinski genom (eng.
Petar Brlek, Dragan Primorac
doaj   +1 more source