Results 31 to 40 of about 174,007 (375)

Contribution of common and rare variants to bipolar disorder susceptibility in extended pedigrees from population isolates. [PDF]

, 2020
Current evidence from case/control studies indicates that genetic risk for psychiatric disorders derives primarily from numerous common variants, each with a small phenotypic impact. The literature describing apparent segregation of bipolar disorder (BP)
Aldana, Ileana, Araya, Carmen, Araya, Xinia, Bearden, Carrie E, Bedoya, Gabriel, Bejarano, Julio, Cantor, Rita M, Castrillón, Gabriel, Coppola, Giovanni, Escobar, Javier I, Fears, Scott C, Freimer, Nelson B, Gomez-Makhinson, Juliana, Huang, Alden Y, Hwang, Sun-Goo, Kremeyer, Barbara, Lopez, Maria C, Lopez-Jaramillo, Carlos, Macaya, Gabriel, Molina, Julio, Montoya, Claudia P, Montoya, Gabriel, Mullins, Niamh, Olde Loohuis, Loes M, Ophoff, Roel A, Ori, Anil PS, Ospina-Duque, Jorge, Park, YoungJun, Ramensky, Vasily, Ramirez, Margarita, Reus, Victor, Ruiz-Linares, Andres, Sabatti, Chiara, Service, Susan K, Spesny, Mitzi, Sul, Jae Hoon, Teshiba, Terri M, Zhang, Zhongyang   +37 more
core   +3 more sources

PulseNet International: Vision for the implementation of whole genome sequencing (WGS) for global food-borne disease surveillance

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2017
PulseNet International is a global network dedicated to laboratory-based surveillance for food-borne diseases. The network comprises the national and regional laboratory networks of Africa, Asia Pacific, Canada, Europe, Latin America and the Caribbean ...
C. Nadon, I. Van Walle, P. Gerner-Smidt, Josefina Campos, I. Chinen, Jeniffer Concepción-Acevedo, B. Gilpin, A. Smith, K. Kam, E. Perez, E. Trees, K. Kubota, J. Takkinen, E. M. Nielsen, H. Carleton   +14 more
semanticscholar   +1 more source

Added Value of Clinical Sequencing: WGS-Based Profiling of Pharmacogenes

International Journal of Molecular Sciences, 2020
Although several pharmacogenetic (PGx) predispositions affecting drug efficacy and safety are well established, drug selection and dosing as well as clinical trials are often performed in a non-pharmacogenetically-stratified manner, ultimately burdening ...
S. Caspar, Timo Schneider, J. Meienberg, G. Mátyás   +3 more
semanticscholar   +1 more source

Whole Genome Sequencing of KI Polyomavirus Strain from Patient with Breast Cancer in Basrah City [PDF]

Journal of Bioscience and Applied Research
Background: Polyomaviruses are small, circular, non-enveloped viruses with a diameter of about 40–50 nm, and have a double-stranded DNA molecule descended from the Polyomaviridae. 32 PyV strains are described, more than 10 of which are reported to infect
akeel Alabadi, Hayder Al-Hmudi, Hassan Habib   +2 more
doaj   +1 more source

Discordant bioinformatic predictions of antimicrobial resistance from whole-genome sequencing data of bacterial isolates: an inter-laboratory study. [PDF]

, 2019
Antimicrobial resistance (AMR) poses a threat to public health. Clinical microbiology laboratories typically rely on culturing bacteria for antimicrobial-susceptibility testing (AST).
Aller, SD, Bruchmann, S, Clark, T, Coello Pelegrin, A, Cormican, M, Diez Benavente, E, Doyle, RM, Ellington, MJ, Harris, KA, Huggett, JF, McGrath, E, Moran-Gilad, J, Motro, Y, O'Sullivan, DM, Phelan, J, Phuong Thuy Nguyen, T, Shaw, LP, Stabler, RA, van Belkum, A, van Dorp, L, Woodford, N   +20 more
core   +4 more sources

Attitudes of geneticists and patients toward incidental findings in Saudi Arabia

Journal of Biochemical and Clinical Genetics, 2019
Background: In Middle East countries, including Saudi Arabia, 60%–70% of all marriages occur between first cousins, leading to uniquely common genetic disorders compared to Western countries.
Taghrid Aloraini, Alya Abdulrahim, Gulsan A. Karbani   +2 more
doaj   +1 more source

Status and potential of bacterial genomics for public health practice : a scoping review [PDF]

, 2019
Background: Next-generation sequencing (NGS) is increasingly being translated into routine public health practice, affecting the surveillance and control of many pathogens.
Boon, Nele AM, Descamps, Tine, Devleesschauwer, Brecht, Robert, Annie, Roosens, Nancy HC, Van Goethem, Nina, Van Oyen, Herman   +6 more
core   +2 more sources

WGS-Based Prediction and Analysis of Antimicrobial Resistance in Campylobacter jejuni Isolates From Israel

Frontiers in Cellular and Infection Microbiology, 2020
Rapid developments in the field of whole genome sequencing (WGS) make in silico antimicrobial resistance (AMR) a target within reach. Campylobacter jejuni is a leading cause of foodborne infections in Israel with increasing rates of resistance.
A. Rokney, L. Valinsky, K. Vranckx, N. Feldman, V. Agmon, J. Moran-Gilad, M. Weinberger   +6 more
semanticscholar   +1 more source

Clinical sequencing: is WGS the better WES?

Human Genetics, 2016
Current clinical next-generation sequencing is done by using gene panels and exome analysis, both of which involve selective capturing of target regions. However, capturing has limitations in sufficiently covering coding exons, especially GC-rich regions.
J. Meienberg, R. Bruggmann, K. Oexle, G. Mátyás   +3 more
semanticscholar   +1 more source

Factors Contributing to the Evolution of mecA-Mediated β-lactam Resistance in Staphylococci: Update and New Insights From Whole Genome Sequencing (WGS)

Frontiers in Microbiology, 2018
The understanding of the mechanisms of antibiotic resistance development are fundamental to alert and preview beforehand, the large scale dissemination of resistance to antibiotics, enabling the design of strategies to prevent its spread.
M. Miragaia
semanticscholar   +1 more source