Hatching of whipworm eggs induced by bacterial contact is serine-protease dependent. [PDF]
PLoS PathogensWhipworms (Trichuris spp) are ubiquitous parasites of humans and domestic and wild mammals that cause chronic disease, considerably impacting human and animal health.
David Goulding +8 more
doaj +4 more sources
A drug repurposing screen for whipworms informed by comparative genomics. [PDF]
PLoS Neglected Tropical Diseases, 2023 Hundreds of millions of people worldwide are infected with the whipworm Trichuris trichiura. Novel treatments are urgently needed as current drugs, such as albendazole, have relatively low efficacy.
Avril Coghlan +14 more
doaj +5 more sources
A genome-scale metabolic model of parasitic whipworm [PDF]
Nature Communications, 2023 Genome-scale metabolic models are widely used to enhance our understanding of metabolic features of organisms, host-pathogen interactions and to identify therapeutics for diseases.
Ömer F. Bay +4 more
doaj +4 more sources
An Unpleasant Souvenir: Whipworm as an Incidental Finding During a Screening Colonoscopy [PDF]
Journal of Investigative Medicine High Impact Case ReportsTrichuriasis is a neglected tropical disease caused by Trichuris trichiura that spreads through the ingestion of embryonated eggs in contaminated soil, water, or food.
Lefika Bathobakae MD, MPH +8 more
doaj +4 more sources
Whipworm-Associated Intestinal Microbiome Members Consistent Across Both Human and Mouse Hosts [PDF]
Frontiers in Cellular and Infection Microbiology, 2021 The human whipworm Trichuris trichiura infects 289 million people worldwide, resulting in substantial morbidity. Whipworm infections are difficult to treat due to low cure rates and high reinfection rates.
Bruce A. Rosa +12 more
doaj +2 more sources
Whipworm infection remodels the gut microbiome ecosystem and compromises intestinal homeostasis in elderly patients revealed by multi-omics analyses [PDF]
Frontiers in Cellular and Infection MicrobiologyIntroductionWhipworm (Trichuris trichiura) coexists with symbiotic microbiota in the gastrointestinal ecosystem. There is a paucity of data on the association between whipworm infection and the gut microbiota composition in elderly individuals.
Benguang Zhang +15 more
doaj +2 more sources
Bacterial contact induces polar plug disintegration to mediate whipworm egg hatching. [PDF]
PLoS Pathogens, 2023 The bacterial microbiota promotes the life cycle of the intestine-dwelling whipworm Trichuris by mediating hatching of parasite eggs ingested by the mammalian host.
Amicha Robertson +15 more
doaj +2 more sources
Transcriptional responses of mouse proximal colon and colonoids during early whipworm infection [PDF]
mBioTrichuriasis, caused by the parasitic nematode Trichuris trichiura, affects 429–508 million people worldwide. Although the early phase of whipworm infection is crucial for establishing infection, its underlying molecular mechanisms remain unclear.
Hyeim Jung +3 more
doaj +2 more sources
Infection with male and female Trichuris trichiura diagnosed in a non‐endemic area [PDF]
Clinical Case Reports, 2023 Key Clinical Message Trichuris trichiura parasitizes only humans through fecal‐oral transmission. In non‐endemic areas, the frequency of endoscopic identification has been increasing due to the increasing number of immigrants from endemic countries.
Masaki Inoue +5 more
doaj +2 more sources
Safety of viable embryonated eggs of the whipworm Trichuris suis as a novel food pursuant to Regulation (EU) 2015/2283 [PDF]
EFSA Journal, 2019 Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on viable embryonated eggs of the whipworm Trichuris suis as a novel food (NF) pursuant to Regulation (EU)
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) +29 more
doaj +2 more sources